Results 81 to 90 of about 147,965 (298)

Optimal Algorithm for Gut Microbiota Differentiation: A Pilot Study of Adolescents with Different Body Weights

Frontiers in Bioscience-Scholar
Background: The enterotype concept allows the differentiation of gut microbiota in relation to individual characteristics and is determined by the genetics and external stressors of the host.
Natalia Belkova, Elizaveta Klimenko, Natalya Semenova, Anna Pogodina, Lyubov Rychkova, Olga Bugun, Lubov Kolesnikova, Marina Darenskaya   +7 more
doaj   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model

Gut Microbes, 2019
Background and aims Bacteriotherapy aimed at addressing dysbiosis may be therapeutic for Inflammatory Bowel Diseases (IBDs). We sought to determine if defined Bacteroides-based bacteriotherapy could be an effective and consistent alternative to fecal ...
Faith D. Ihekweazu, Tatiana Y. Fofanova, Karen Queliza, Dorottya Nagy-Szakal, Christopher J. Stewart, Melinda A. Engevik, Kristina G. Hulten, Nina Tatevian, David Y. Graham, James Versalovic, Joseph F. Petrosino, Richard Kellermayer   +11 more
doaj   +1 more source

Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients [PDF]

, 2017
The gut microbiota has a crucial effect on human health and physiology. Hypothyroid Hashimoto’s thyroiditis (HT) is an autoimmune disorder manifested with environmental and genetic factors.
Guo, Hui, Hou, Yin Jian, Ishaq, Hafiz Muhammad, Ma, Chaofeng, Mohammad, Imran Shair, Naseem, Zahid, Shahzad, Muhammad, Shi, Peijie, Wu, Xiaokang, Xu, Jiru   +9 more
core   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. [PDF]

, 2014
BackgroundBacteroides spp. form a significant part of our gut microbiome and are well known for optimized metabolism of diverse polysaccharides. Initial analysis of the archetypal Bacteroides thetaiotaomicron genome identified 172 glycosyl hydrolases and
Axelrod, Herbert L, Chang, Yuanyuan, Eberhardt, Ruth Y, Godzik, Adam, Li, Zhanwen, Rigden, Daniel J, Sheydina, Anna, Zmasek, Christian C   +7 more
core   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Modelling the emergent dynamics and major metabolites of the human colonic microbiota [PDF]

, 2015
Funded by Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS) Acknowledgements We would like to thank Thanasis Vogogias, David Nutter and Alec Mann for their assistance in developing the software for this model ...
Aminov, Bagramyan, Barcenilla, Bratbak, Cotillard, David, Drake, Duncan, Duncan, Duncan, Duncan, Duncan, Duncan, Eckburg, Egert, Feijó Delgado, Filippo, Flint, Flint, Flint, Gottschalk, Kettle, Kovarova-Kovar, Latham, Liu, Lopez-Siles, Louis, Louis, Macfarlane, Marquet, Moore, Munoz-Tamayo, Nava, Norberg, Prins, Qin, Ragsdale, Reichardt, Richardson, Robert, Rogers, Russell, Salyers, Seeliger, Stephen, Swidsinski, Tap, Turnbaugh, Walker, Walker, Walker, Whitman, Wolin, Wu, Yachi, Ze   +55 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Prebiotic effects: metabolic and health benefits [PDF]

, 2010
The different compartments of the gastrointestinal tract are inhabited by populations of micro-organisms. By far the most important predominant populations are in the colon where a true symbiosis with the host exists that is a key for well-being and ...
Agnes Meheust, Anne L. McCartney, Audrey M. Neyrinck, Balsari, Ben, Bernd Stahl, Bernhard Watzl, Blaut, Brommage, Caderni, Caers, Cashman, Cashman, Chassard, Coudray, Cummings, Danielle Wolvers, de Vrese, Dughera, Engelhardt, Fava, Francisco Guarner, Franck, Frederique Respondek, Gibson, Girrbach, Glenn R. Gibson, Gray, Griffin, Hanai, Hania Szajewska, Harmsen, Hawthorne, Hudson, Hughes, Hussey, Ian Rowland, Irvine, Irvine, Kanauchi, Kelly, Kevin Whelan, Kim, Klobukowski, Kobayashi, Laurent Léotoing, Lesley Hoyles, Levitt, Lien do, Macfarlane, Macfarlane, Marcel Roberfroid, Marie-Jeanne Davicco, Mathey, Morand, Murphy, Nathalie M. Delzenne, Ng, O'Connor, O'May, Ohta, Ohta, Patrice D. Cani, Perrin, Pierre, Quigley, Rayssiguier, Reddy, Remesy, Reshef, Reuter, Richardson, Roberfroid, Roberfroid, Roberfroid, Roberfroid, Roberfroid, Robert Rastall, Rondon, Rowland, Sakaguchi, Schaafsma, Sellon, Siong, Suau, Taper, van Dokkum, Veronique Coxam, Vulevic, Wada, Walker, Wilson, Yohann Wittrant, Zoetendal, Zoetendal   +94 more
core   +3 more sources