Results 131 to 140 of about 129,877 (288)

Changes in the gut microbiome during fasting‐induced molting and its effects on gut–liver function

iMetaOmics, EarlyView.
During fasting, harmful microbiota and metabolites rise, triggering intestinal injury and activation of the TGF‐β signaling pathway, which enhances intestinal stem cell proliferation. Concurrently, hepatic function declines, indicated by increased hepatic and serum bile acids and upregulation of the non‐classical bile acid synthesis pathway.
Hao Zhang, Zhixuan Luo, Jun Zhang, Chenxu Wang, Yadong Tian, Donghua Li, Yujie Guo, Yanhua Zhang, Wenting Li, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +11 more
wiley   +1 more source

Distribution and evolution of nitrogen fixation genes in the phylum Bacteroidetes.

Microbes and environments, 2015
Diazotrophs had not previously been identified among bacterial species in the phylum Bacteroidetes until the rapid expansion of bacterial genome sequences, which revealed the presence of nitrogen fixation (nif) genes in this phylum. We herein determined the draft genome sequences of Bacteroides graminisolvens JCM 15093(T) and Geofilum rubicundum JCM ...
Jun-Ichi Inoue, Kenshiro Ohshima, Wataru Suda, Mitsuo Sakamoto, Takao Iino, Satoko Noda, Yuichi Hongoh, Masahira Hattori, Moriya Ohkuma   +8 more
openaire   +2 more sources

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source

Research progress on regulation of gut microbiota abundance induced by ambient particulate matter exposure

环境与职业医学
Particulate matter (PM) is the main air pollutant in China. Due to its wide distribution and difficulties in control, PM has been widely concerned.
Yaohan WANG, Nannan HUANG, Bin LI, Hanqing CHEN, Xiaobo LI, Rui CHEN   +5 more
doaj   +1 more source

Hepatoprotective Potential of Walnut Oil Unsaponifiable Matter on Aging-Induced Liver Injury via Gut Microbiota-Liver Axis. [PDF]

Food Sci Nutr
USM protects against aging‐induced liver injury by modulating the gut‐liver axis. It enriches beneficial microbiota (e.g., Akkermansia and Lactobacillus) and upregulates tight junction proteins (ZO‐1, Occludin, Claudin) to restore the intestinal barrier.
Zhou J, Hong D, Bai R, Wang X, Zhu S, Tian Q, Xia J, Chen Z, Li S, Jia Y, Ma A.   +10 more
europepmc   +2 more sources

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

iMeta, EarlyView.
Longitudinal multi‐omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low‐grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age‐discordant dysbiosis, including altered ...
Ting Zhang, Xiaopeng Wang, Peng Li, Junyu Zhang, Wenjie Sun, Zhen Zhang, Yan Zhuo, Wenting Guo, Yongchang Chen   +8 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins. [PDF]

, 2018
Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other
Barry, Natasha A, Degnan, Patrick H, Folta-Stogniew, Ewa, Goodman, Andrew L, Schofield, Whitman B, Wexler, Aaron G   +5 more
core  

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source