Results 31 to 40 of about 232,449 (132)

Selective targeting of NOTCH-1 for therapeutic purposes in xenograft models of T-acute lymphoblastic leukemia [PDF]

, 2013
T-cell acute lymphoblastic leukemia (T-ALL) is an heterogeneous disease, characterized by several genetic alterations and polymorphic clinical features both in children and adults.
Agnusdei, Valentina
core  

Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]

, 2008
Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core   +1 more source

Genomic Landscape of Acute Lymphoblastic Leukemia (ALL): Insights to Leukemogenesis, Prognostications, and Treatment

, 2023
Acute lymphoblastic leukemia is a heterogenous disease under the current WHO 2017 classification. The prognosis in certain subgroups of patients is particularly poor with limited treatment options available. Moreover, risk stratification was difficult in
Sin, Chun Fung
core   +1 more source

Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia

, 2008
The intrachromosomal amplification of chromosome 21 (iAMP21) was identifiedas a novel and prognositically important acquired chromosomal abnormality inchildhood acute lymphoblastic leukaemia (ALL).
Robinson, Hazel M.
core   +2 more sources

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T., J. Mittermueller, D. Wiesner, S. Braun, H.M. Schmetzer, T. Duell, H.H. Gerhartz   +11 more
core   +1 more source

Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?

Haematologica, 2012
Background Precursor B-acute lymphoblastic leukemia occurring in patients with a history of malignancies is uncommon, and this condition is not well understood.Design and Methods A retrospective review of 457 adults with precursor B-acute lymphoblastic ...
Guilin Tang, Zhuang Zuo, Deborah A. Thomas, Pei Lin, Dingsheng Liu, Ying Hu, Hagop M. Kantarjian, Carlos Bueso-Ramos, L. Jeffrey Medeiros, Sa A. Wang   +9 more
doaj   +1 more source

Optic neuropathy associated with GVHD after bone marrow allogeneic hematopoietic stem cell transplantation for B-Acute lymphoblastic leukemia: case report

BMC Ophthalmology, 2022
Background Graft-versus-host disease (GVHD) is the most common complication after bone marrow allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Bowen Wang, Fagang Jiang, Xinghua Wang
doaj   +1 more source

Risk assessment of FLT3 and PAX5 variants in B-acute lymphoblastic leukemia: a case–control study in a Pakistani cohort [PDF]

PeerJ, 2019
AIMS B-cell acute lymphoblastic leukemia (B-ALL) is amongst the most prevalent cancers of children in Pakistan. Genetic variations in FLT3 are associated with auto-phosphorylation of kinase domain that leads to increased proliferation of blast cells ...
Ammara Khalid, Sara Aslam, Mehboob Ahmed, Shahida Hasnain, Aimen Aslam   +4 more
doaj   +2 more sources

Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia

, 2015
In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard imatinib/hyperCVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) therapy (arm B) in 268 ...
Cayuela, Jean-Michel, Huguet, Françoise, Maury, Sébastien, Chalandon, Yves, Lepretre, S., Ifrah, N., Berthon, C., Chevret, S., Escoffre-Barbe, Martine, Dombret, Hervé, Lepretre, Stéphane, Rousselot, Philippe, Thomas, X., Escoffre-Barbe, M., Maury, S., Tavernier, E., Hayette, Sandrine, Tavernier, Emmanuelle, Berthon, Céline, Lhéritier, V., Raffoux, E., Lafage-Pochitaloff, M., Cayuela, J.M., Abbal, C., Chalandon, Y., Thomas, Xavier, Leguay, Thibaut, Chevret, Sylvie, Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), Leguay, T., Rousselot, P., Lambert, Jean-François, Abbal, Claire, Hayette, S., Lafage-Pochitaloff, Marina, Lhéritier, Véronique, Huguet, F., Lambert, J.F., Raffoux, Emmanuel, Ifrah, Norbert, Dombret, H.   +40 more
core   +1 more source

An acquired stable variant of a dicentric dic(9;20) and complex karyotype in a Syrian childhood B-acute lymphoblastic leukemia case

Molecular Cytogenetics, 2020
Background About 25 years ago, the acquired chromosome abnormality dicentric dic(9;20)(p11 ~ 13;q11) was seen described as a non-random aberration in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet, about 200 cases were reported.
Abdulsamad Wafa, Rami A. Jarjour, Abdulmunim Aljapawe, Suher ALmedania, Thomas Liehr, Joana B. Melo, Isabel M. Carreira, Moneeb A. K. Othman, Walid Al-Achkar   +8 more
doaj   +1 more source