Results 61 to 70 of about 33,886 (209)
Expanding the phenotype associated with SMARCC2 variants: a fetus with tetralogy of Fallot
BMC Medical Genomics, 2022 Background Coffin-Siris syndrome-8 (CSS8) is a rare autosomal dominant disorder caused by variants in SMARCC2, a core subunit of the chromatin-remodeling complex BRG1-associated factor (BAF).
Hairui Sun +6 more
doaj +1 more source
BAF45b Is Required for Efficient Zika Virus Infection of HAP1 Cells
Viruses, 2021 The 2016 Zika virus (ZIKV) epidemic illustrates the impact of flaviviruses as emerging human pathogens. For unknown reasons, ZIKV replicates more efficiently in neural progenitor cells (NPCs) than in postmitotic neurons.
B. David Persson +8 more
doaj +1 more source
Mineralogical Characterization of Baptistina Asteroid Family: Implications for K/T Impactor Source
, 2011 Bottke et al. (2007) linked the catastrophic formation of Baptistina Asteroid Family (BAF) to the K/T impact event. This linkage was based on dynamical and compositional evidence, which suggested the impactor had a composition similar to CM2 carbonaceous
Candal, Alvaro Alvarez +10 more
core +1 more source
Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain [PDF]
Cell, 2017 Alterations in transcriptional regulators can orchestrate oncogenic gene expression programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, which is mutated in over 20% of human tumors, interacts with EWSR1, a member of a family of proteins with prion-like domains (PrLD) that are frequent partners in ...
Boulay, Gaylor +14 more
openaire +5 more sources
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes.
PLoS ONE, 2012 BackgroundNucleosome translocation along DNA is catalyzed by eukaryotic SNF2-type ATPases. One class of SNF2-ATPases is distinguished by the presence of a C-terminal bromodomain and is conserved from yeast to man and plants.
Evelien Middeljans +5 more
doaj +1 more source
A cell-based assay for CD63-containing extracellular vesicles [PDF]
, 2019 Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are few.
Cashikar, Anil G, Hanson, Phyllis I
core +2 more sources
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 During the last decade, a host of epigenetic mechanisms were found to contribute to cancer and other human diseases. Several genomic studies have revealed that ∼20% of malignancies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) complexes, making them among the most frequently mutated
Courtney, Hodges +2 more
openaire +2 more sources
Communications Biology, 2022 The ancestral history of SWI/SNF subunits, responsible for nucleosome positioning, are explored in this work, revealing a plant SWI/SNF complex similar to the animal BAF subclass.
Jorge Hernández-García +8 more
doaj +1 more source
Barium fluoride whispering-gallery-mode disk-resonator with one billion quality-factor
, 2014 We demonstrate a monolithic optical whispering gallery mode resonator fabricated with barium fluoride (BaF$_2$) with an ultra-high quality ($Q$) factor above $10^9$ at $1550$ nm, and measured with both the linewidth and cavity-ring-down methods. Vertical
Chembo, Yanne K. +4 more
core +1 more source
Reconstructing DNA copy number by joint segmentation of multiple sequences [PDF]
, 2012 The variation in DNA copy number carries information on the modalities of genome evolution and misregulation of DNA replication in cancer cells; its study can be helpful to localize tumor suppressor genes, distinguish different populations of cancerous ...
Lange, Kenneth +2 more
core +4 more sources