Results 81 to 90 of about 33,886 (209)
Advanced Science, EarlyView.We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng +8 more
wiley +1 more source
Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states [PDF]
Nature Genetics, 2016 The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the underlying mechanisms remain unclear, owing largely to a lack of assays to assess BAF function in living ...
Cigall Kadoch +8 more
openaire +4 more sources
Molecular Cancer, 2022 Background Epigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the initiation of embryonal tumour development.
Carlos Jiménez +16 more
doaj +1 more source
Insights Into the Emerging Role of Baf53b in Autism Spectrum Disorder
Frontiers in Molecular Neuroscience, 2022 Accurate and precise regulation of gene expression is necessary to ensure proper brain development and plasticity across the lifespan. As an ATP-dependent chromatin-remodeling complex, the BAF (Brg1 Associated Factor) complex can alter histone-DNA ...
Megan E. Rowland +3 more
doaj +1 more source
A liquid chromatography tandem mass spectrometry method for simultaneous analysis of 46 atmospheric particulate-phase persistent organic pollutants and comparison with gas chromatography/mass spectrometry, [PDF]
, 2017 A novel multi-analyte method for the simultaneous determination of 46 compounds of environmental concern, most of them belonging to the category of persistent organic pollutants, was developed using high-performance liquid chromatography and the results ...
Buiarelli, Francesca +4 more
core +1 more source
Advanced Science, EarlyView.This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang +10 more
wiley +1 more source
Life Science Alliance, 2021 We have addressed the mechanisms by which the fusion protein SS18-SSX modifies the epigenome toward the development of synovial sarcoma and the establishment of its potentially targetable vulnerabilities.
Gaylor Boulay +25 more
doaj +1 more source
Zeroth order regular approximation approach to electric dipole moment interactions of the electron
, 2017 A quasi-relativistic two-component approach for an efficient calculation of $\mathcal{P,T}$-odd interactions caused by a permanent electric dipole moment of the electron (eEDM) is presented. The approach uses a (two-component) complex generalized Hartree-
Berger, Robert, Gaul, Konstantin
core +1 more source
Integrating Smart Ceiling Fans and Communicating Thermostats to Provide Energy-Efficient Comfort [PDF]
, 2020 The project goal was to identify and test the integration of smart ceiling fans and communicating thermostats. These highly efficient ceiling fans use as much power as an LED light bulb and have onboard temperature and occupancy sensors for automatic ...
Arens, Edward +12 more
core
Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]
, 2008 A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González +4 more
core +4 more sources