Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways
Molecules, 2023 Baicalin is an active ingredient extracted from the Chinese medicine Scutellaria and has many beneficial effects. Pulmonary interstitial and alveolar edema are common symptoms of an acute lung injury (ALI).
Bingyu Shen +6 more
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Baicalin inhibits infectious bronchitis virus replication via MAVS-dependent interferon-β upregulation and mitochondrial function preservation [PDF]
Scientific ReportsThe inhibitory effect of baicalin on infectious bronchitis virus (IBV) replication is closely related to expression of the mitochondrial antiviral signaling protein (MAVS) in chicken embryonic kidney (CEK) cells.
Jiongjie He +3 more
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The Pharmacological Efficacy of Baicalin in Inflammatory Diseases
International Journal of Molecular Sciences, 2023 Baicalin is one of the most abundant flavonoids found in the dried roots of Scutellaria baicalensis Georgi (SBG) belonging to the genus Scutellaria.
Yongqiang Wen +4 more
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BMC Complementary Medicine and Therapies, 2023 Baicalin magnesium is a water-soluble compound isolated from the aqueous solution by Scutellaria baicalensis Georgi. Preliminary experiments have demonstrated that baicalin magnesium can exert protective effects against acute liver injury in rats induced
Xiulu Guan +8 more
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Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model [PDF]
PLoS ONE, 2017 The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa.
Jing Luo
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The effects of baicalein and baicalin on mitochondrial function and dynamics: A review [PDF]
Pharmacological Research, 2015 Mitochondria play an essential role in cell survival by providing energy, calcium buffering, and regulating apoptosis. A growing body of evidence shows that mitochondrial dysfunction and its consequences, including impairment of the mitochondrial ...
Marcos Roberto de Oliveira +2 more
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Journal of Bone Oncology, 2022 Baicalin, a flavonoid derivative, exerts antitumor activity in a variety of neoplasms. However, whether baicalin exerts antitumor effects on osteosarcoma cells remains to be elucidated. In this study, treatment with baicalin reduced the proliferation and
He Pang +7 more
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Protective effect of baicalin against cognitive memory dysfunction after splenectomy in aged rats and its underlying mechanism [PDF]
Journal of Integrative Neuroscience, 2020 Postoperative cognitive dysfunction is a common neurological complication, characterized by impaired learning and memory, that occurs after anesthesia and surgery, especially in elderly patients. The traditional Chinese medicine baicalin is known to have
Jian-Nan Zhang +4 more
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BMC Complementary Medicine and Therapies, 2022 Background Baicalin is a generally available flavonoid with potent biological activity. The present study aimed to assess the underlying mechanism of baicalin in treatment of atherosclerosis (AS) with the help of network pharmacology, molecular docking ...
Mingshuang Li, Conglin Ren
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Baicalin protects the cardiomyocytes from ER stress-induced apoptosis: inhibition of CHOP through induction of endothelial nitric oxide synthase. [PDF]
PLoS ONE, 2014 Baicalin, the main active ingredient of the Scutellaria root, exerts anti-oxidant and anti-apoptotic effects in cardiovascular diseases. However, the therapeutic mechanism of baicalin remains unknown. Cultured neonatal rat cardiomyocytes were pre-treated
Mingzhi Shen +14 more
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