Results 201 to 210 of about 20,980 (270)

Electrochemical investigations of baicalin and DNA?baicalin interactions

Analytical and Bioanalytical Chemistry, 2004
Baicalin is an anti-HIV drug purified from the traditional Chinese medicinal plant Scutellaria Baicalensis Georgi. Baicalin has proven to be electroactive at pyrolytic graphite (PG) electrodes. We thus studied its interaction with DNA via the electrochemical approach. We observed that the peak currents corresponding to the baicalin reduction-oxidation (
Ziyi, Sun, Zhong, Ma, Wenjun, Zhang, Xiaoyue, Wang, Chunhai, Fan, Genxi, Li   +5 more
openaire   +2 more sources

Baicalin inhibits influenza A (H1N1)‐induced pyroptosis of lung alveolar epithelial cells via caspase‐3/GSDME pathway

Journal of Medical Virology, 2023
Baicalin (7‐d‐glucuronic acid‐5, 6‐dihydroxyflavone) derived from the root of Scutellaria baicalensis used as Traditional Chinese Medicine (TCM) has been revealed to exert potential antiviral activity via various pathways, while the molecular mechanisms ...
Zhenqiao Wei, Rui Gao, Zhen-Yang Sun, Wen Yang, Q. He, Chenhui Wang, Jingxian Zhang, Xiaochang Zhang, Liang Guo, Shengqi Wang   +9 more
semanticscholar   +1 more source

Baicalin, a natural LSD1 inhibitor

Bioorganic Chemistry, 2016
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01μM and showed strong LSD1 inhibitory ...
Yi-Chao, Zheng, Dan-Dan, Shen, Meng, Ren, Xue-Qi, Liu, Zhi-Ru, Wang, Ying, Liu, Qian-Na, Zhang, Li-Juan, Zhao, Li-Jie, Zhao, Jin-Lian, Ma, Bin, Yu, Hong-Min, Liu   +11 more
openaire   +2 more sources

An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

Iranian Journal of Basic Medical Sciences, 2022
The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis Georgi.
Zhi-xing Hu, Yurong Guan, Wanying Hu, Zhiyong Xu, Muhammad Ishfaq   +4 more
semanticscholar   +1 more source

Hydroxylethylation of baicalin by γ-ray irradiation of baicalin in ethanol

Radiation Physics and Chemistry, 1996
Via γ-irradiation of baicalin in ethanol, hydroxylethyl groups were introduced into B and C rings of baicalin. Eight hydroxylethylation products were separated by reverse HPLC and their molecular structures were postulated through their UV, IR, MS and fluorescence spectra. The primary binding constants of baicalin and its hydroxylethylation products in
Cai Zhongli, He Yongke, Wu Jilan
openaire   +1 more source

Baicalin-Aluminum Modulates the Broiler Gut Microbiome

DNA and Cell Biology, 2021
Baicalin-aluminum regulates the gut microbiome of piglets with diarrhea. However, whether it affects poultry gut microbiome composition and function remains unknown. In this study, we used metagenomic sequencing to explore the effects of baicalin-aluminum on gut microbiome changes in poultry when compared with animals administered colistin sulfate. Our
Ling Guo, Jing He, Jiacheng Zhang, Xiaofang Zhang, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Shulin Fu, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Chien-An Andy Hu   +12 more
openaire   +2 more sources

Baicalin mitigated IL‐1β‐Induced osteoarthritis chondrocytes damage through activating mitophagy

Chemical Biology and Drug Design, 2023
Mitophagy is related to chondrocyte homeostasis and plays a key role in the progress of osteoarthritis (OA). Baicalin has a protective effect on OA chondrocytes, the aim of this study was to explore whether the effect of Baicalin on IL‐1β‐induced ...
Jun He, Jian He
semanticscholar   +1 more source

Chrysin and baicalin in diabetic nephropathy

Environmental Toxicology and Pharmacology, 2017
[no abstract available]
Chirumbolo, Salvatore, Bjørklund, Geir
openaire   +3 more sources

Framework Nucleic Acid-Based and Neutrophil-Based Nanoplatform Loading Baicalin with Targeted Drug Delivery for Anti-Inflammation Treatment.

ACS Nano
Targeted drug delivery is a promising strategy for treating inflammatory diseases, with recent research focusing on the combination of neutrophils and nanomaterials.
Mi Zhou, Yuanlin Tang, Yifei Lu, Tianxu Zhang, Shunhao Zhang, Xiaoxiao Cai, Yunfeng Lin   +6 more
semanticscholar   +1 more source

Baicalin Attenuates Laser-Induced Choroidal Neovascularization

Current Eye Research, 2014
To determine whether intravitreally-injected baicalin inhibits the growth of choroidal neovascularization (CNV) experimentally induced via laser photocoagulation through analysis of angiogenic factors.Six CNVs were induced in the left eyes of 8-week-old male Brown Norway rats. Immediately after the induction of CNV, 4 μl of baicalin solution (0.1, 1 or
Sung Jae, Yang, Hyoung, Jo, June-Gone, Kim, Sang Hoon, Jung   +3 more
openaire   +2 more sources