Results 61 to 70 of about 11,830 (227)

Table_1_SbWRKY75- and SbWRKY41-mediated jasmonic acid signaling regulates baicalin biosynthesis.docx

, 2023
IntroductionScutellaria baicalensis Georgi is a traditional Chinese medicinal plant with broad pharmacological activities whose main active ingredient is the flavonoid baicalin.
Shi Qiu (425335), Shi Qiu, Zongyou Lv (378800), Wansheng Chen (190172), Kaixian Chen, Kaixian Chen (19449), Shiyuan Fang, Ying Xiao (6517), Chen Zhang (66790), Chen Zhang, Zongyou Lv, Ying Xiao, Shiyuan Fang (7280018), Wansheng Chen   +13 more
core   +1 more source

Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model

Cellular Physiology and Biochemistry, 2017
Background/Aims: Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury.
Yanqing Zhang, Pingping Liao, Meng’en Zhu, Wei Li, Dan Hu, Siming Guan, Long Chen   +6 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Baicalin Improves Antioxidant Status of Streptozotocin-Induced Diabetic Wistar Rats

, 2016
This study investigated the antioxidant and antidiabetic effects of baicalin, as well as its effects in combination with the antidiabetic drug metformin. Three groups of streptozotocin-induced diabetic rats were given the following treatments for 30 days:
Annie Hsu (330347), Benny Kwong-Huat Tan (2372527), Viduranga Y. Waisundara (2372524), Dejian Huang (413516)   +3 more
core   +1 more source

Baicalin prevents Candida albicans infections via increasing its apoptosis rate [PDF]

, 2014
BackgroundThese experiments were employed to explore the mechanisms underlying baicalin action on Candida albicans.Methodology and principal findingsWe detected the baicalin inhibition effects on three isotope-labeled precursors of 3H-UdR, 3H-TdR and 3H ...
Yang, Shulong, Xu, Jing, Fu, Yingyuan, Wu, Xiuzhen, Zeng, Xiaoping, Kuang, Nanzhen, Zhou, Zhixing, Zeng, Yurong   +7 more
core   +1 more source

Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm

Frontiers in Pharmacology, 2022
Background: Cytokine storm (CS) is a systemic inflammatory syndrome and a major cause of multi-organ failure and even death in COVID-19 patients. With the increasing number of COVID-19 patients, there is an urgent need to develop effective therapeutic ...
Jia You, Huawei Li, Peng Fan, Xi Yang, Yuanfeng Wei, Lingnan Zheng, Zhaojun Li, Cheng Yi   +7 more
doaj   +1 more source

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

Structure of baicalin and baicalein.

, 2018
Structure of baicalin and baicalein.
Youlin Zhu (4849585), Xin Yan (17064), Limin Fang (4849576), Shurui Song (4849582), Hu Su (4849579), Bin Zeng (3474053)   +5 more
core   +1 more source

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Journal of Neuroinflammation, 2019
Background Baicalin, which is isolated from Radix Scutellariae, possesses strong biological activities including an anti-inflammation property. Recent studies have shown that the anti-inflammatory effect of baicalin is linked to toll-like receptor 4 ...
Li-Ting Guo, Si-Qi Wang, Jing Su, Li-Xing Xu, Zhou-Ye Ji, Ru-Yi Zhang, Qin-Wen Zhao, Zhan-Qiang Ma, Xue-Yang Deng, Shi-Ping Ma   +9 more
doaj   +1 more source

Consecutive baicalin treatment relieves its accumulation in rats with intrahepatic cholestasis by increasing MRP2 expression

Heliyon, 2023
Baicalin, an important flavonoid isolated from Scutellaria baicalensis Georgi, is a Chinese herb widely used in clinical practice. We previously reported the in vivo accumulation of baicalin in rats with intrahepatic cholestasis (IHC) after a single dose.
Yue Zu, Yanan Liu, Lulu Lan, Chen Zhu, Chengliang Zhang, Dong Liu   +5 more
doaj   +1 more source