Results 71 to 80 of about 10,947 (224)

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Journal of Neuroinflammation, 2019
Background Baicalin, which is isolated from Radix Scutellariae, possesses strong biological activities including an anti-inflammation property. Recent studies have shown that the anti-inflammatory effect of baicalin is linked to toll-like receptor 4 ...
Li-Ting Guo, Si-Qi Wang, Jing Su, Li-Xing Xu, Zhou-Ye Ji, Ru-Yi Zhang, Qin-Wen Zhao, Zhan-Qiang Ma, Xue-Yang Deng, Shi-Ping Ma   +9 more
doaj   +1 more source

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

Integrative Zoology, EarlyView.
The schematic diagram illustrates that the amphibian‐derived peptide OA‐AL14 protects against UVB‐induced skin photoaging through a dual mechanism: activating the Nrf2 pathway to counteract oxidative stress and modulating the AMPK/mTOR axis to induce protective autophagy. ABSTRACT Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a
Ying Peng, Yutong Wu, Zhe Fu, Zijian Kang, Qiuye Jia, Wenbi Zhao, Ziyi Wang, Yuexi Liu, Ruijie Zhang, Yuansheng Li, Zeqiong Ru, Wenrou Su, Naixin Liu, Yilin Li, Saige Yin, Ying Wang, Xinwang Yang   +16 more
wiley   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Dissolution and pharmacokinetics of baicalin–polyvinylpyrrolidone coprecipitate

Journal of Pharmacy and Pharmacology, 2013
Abstract Objectives Baicalin–polyvinylpyrrolidone coprecipitate was prepared with the aim of improving the dissolution and bioavailability of the baicalin. Methods The dissolution of the coprecipitate in capsule form was tested and ...
Bibo, Li, Mei, He, Wei, Li, Zhibin, Luo, Ying, Guo, Yajun, Li, Chunbao, Zang, Bo, Wang, Fang, Li, Shaolin, Li, Ping, Ji   +10 more
openaire   +2 more sources

In vivo activities of Baicalin against Chlamydia trachomatis

, 2012
Our previous studies have shown that Baicalin could effectively inhibit Chlamydia trachomatis in vitro. In this study, Baicalin was tested for potential antichlamydial activity using a murine genital Chlamydia trachomatis infection model.
Yandong, Y, Wen, S, Hao, H, Lei, F, Xiaojuan, Qi   +4 more
core   +1 more source

The effects of baicalin on piglets challenged with Glaesserella parasuis

Veterinary Research, 2020
Glaesserella parasuis (G. parasuis) causes porcine vascular inflammation and damage. Baicalin is reported to have antioxidant and anti-inflammatory functions. However, whether baicalin protects piglets against G.
Shulin Fu, Ronghua Yin, Sanling Zuo, Jun Liu, Yunfei Zhang, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An Andy Hu   +11 more
doaj   +1 more source

Powdered hibiscus anthocyanin‐nanofibril complexes as natural colourants: Stability and application in yoghurt and soft candy

Coloration Technology, EarlyView.
Abstract The instability of anthocyanins limits their application as natural food colorants. This study aimed to enhance the stability of anthocyanins extracted from Hibiscus sabdariffa through copigmentation with protein nanofibrils produced from pea, rice, gluten and whey isolates. Linear and curly nanofibril structures were prepared and incorporated
Vildan Eyiz, İsmail Tontul, Selman Türker   +2 more
wiley   +1 more source

FURIN induces vascular endothelial cell death and efferocytosis through enzymatic cleavage of thrombospondin‐1

The Journal of Physiology, EarlyView.
Abstract figure legend FURIN induces vascular endothelial cell (VEC) death and efferocytosis through enzymatic cleavage of thrombospondin‐1 (THBS1). FURIN interacts with THBS1 to induce VEC apoptosis and efferocytosis, resulting in increased endothelial permeability.
Runji Chen, Daifei Shen, Amandine Mahieux, Dedrick Song, Shiwan Wu, Xiaoxin Huang, Xu Yang, Kunwei Chen, David G. McVey, Elisa A. Liehn, Roshni R. Singaraja, Shu Ye   +11 more
wiley   +1 more source

Biocatalytic Synthesis of Lipophilic Baicalin Derivatives as Antimicrobial Agents

, 2019
Enzymatic acylation is commonly used to increase the lipophilicity of flavonoids. However, the absence of primary hydroxyl groups makes it challenging to acylate baicalin using traditional acylation methods.
Mengmeng Zhang (1507543), Guanglei Zhao (618064), Xuan Xin (4372168), Xiao-Feng Li (368485)   +3 more
core   +1 more source

Study of the antitumor activity of the combination baicalin and epigallocatechin gallate in a murine model of vincristine-resistant breast cancer [PDF]

Pharmacia
Background: Breast cancer is one of the primary causes of death in women worldwide. Yearly, a quarter of cancer cases in women are breast cancer. The problem is aggravated by the emergence of chemotherapeutic resistance.
Dima Awajan, Anas H. A. Abu-Humaidan, Wamidh H. Talib   +2 more
doaj   +3 more sources