Results 91 to 100 of about 10,947 (224)

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

, 2013
Ling Zhao,1,2 Yumeng Wei,1,2 Yu Huang,1 Bing He,2 Yang Zhou,1 Junjiang Fu31Department of Pharmaceutical Sciences, School of Pharmacy, Luzhou Medical College, Luzhou City, Sichuan Province, People's Republic of China; 2Drug and Functional Food ...
Zhao L, Huang Y, Fu J, Zhou Y, Wei Y, He B   +5 more
core  

Baicalin Normalizes Blood Glucose Level in Streptozotocin -induced Diabetic Rats [PDF]

, 2012
This study aimed to determine the effect of baicalin on insulin resistance, glucose absorption, and blood lipids in type 2 diabetic rat model. Diabetic rats were treated with baicalin (40, 80 mg/kg) for 40 days.
Zhao, Chen, Zhang, Liang, Ni, Yuan, Pan, Haixian, Ren, Yumiao, Jia, Guangfeng, Meng, Xiangyan, Lu, Wenzong   +7 more
core  

Pharmacological actions of baicalin and baicalein

Folia Pharmacologica Japonica, 1970
In the Chinese medicine, Scutellaria baicalensis GEORG has been used as a remedy for some of allergic diseases. Therefore, the authors investigated the effects of baicalin and baicalein, components of the drug, on active anaphylactic reaction in guinea pig, and the results obtained were compared with those of rutin, methylhesperidin and quercetin.
KODA, Akihide, NAGAI, Hiroichi, WADA, Hiroshi   +2 more
  +6 more sources

Baicalin protects against hepatocyte injury caused by aflatoxin B1 via the TP53-related ferroptosis Pathway

Ecotoxicology and Environmental Safety
Objective: Baicalin has antioxidative, antiviral, and anti-inflammatory properties. However, its ability to alleviate oxidative stress (OS) and DNA damage in liver cells exposed to aflatoxin B1 (AFB1), a highly hepatotoxic compound, remains uncertain. In
Han-Jing Zhang, Jian-Zhu Luo, Chen-lu Lan, Xiong Teng, Bin Ge, Jun-Qi Liu, Hai-Xiang Xie, Ke-Jian Yang, Chong-Jiu Qin, Xin Zhou, Tao Peng   +10 more
doaj   +1 more source

Process optimization and evaluation of novel baicalin solid nanocrystals

, 2013
Peng-Fei Yue,1,2 Yu Li,1 Jing Wan,1 Yong Wang,1 Ming Yang,1 Wei-Feng Zhu,1 Chang-Hong Wang,2 Hai-Long Yuan31Key Lab of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Nanchang, 2Institute of Chinese Materia Medica, Shanghai
Yuan HL, Li Y, Yue PF, Wang CH, Yang M, Wan J, Zhu WF, Wang Y   +7 more
core  

Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway

Frontiers in Pharmacology, 2017
As a kind of potent stimulus, lipopolysaccharide (LPS) has the ability to cause cell damage by activating toll-like receptor(TLR)4, then nuclear factor kappa B (NF-κB) translocates into the nucleus and changes the expression of related inflammatory genes.
Ping Cheng, Tong Wang, Wei Li, Ishfaq Muhammad, He Wang, Xiaoqi Sun, Yuqi Yang, Jiarui Li, Tianshi Xiao, Xiuying Zhang   +9 more
doaj   +1 more source

Lung-targeting drug delivery system of baicalin-loaded nanoliposomes: development, biodistribution in rabbits, and pharmacodynamics in nude mice bearing orthotopic human lung cancer

, 2016
Yumeng Wei,1 Jing Liang,1 Xiaoli Zheng,2 Chao Pi,1 Hao Liu,1 Hongru Yang,3 Yonggen Zou,4 Yun Ye,1,5 Ling Zhao1 1Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, 2Department of Biochemistry, The Institute of Basic Medical ...
Liu H, Yang H, Zou Y, Zheng X, Zhao L, Liang J, Pi C, Ye Y, Wei Y   +8 more
core  

Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson's disease rats via the mTOR/AKT/GSK-3β pathway

Journal of Integrative Neuroscience, 2019
This focus of our research is to investigate the protective effect of Baicalin on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in a rat model for Parkinson's disease, induced by 6-Hydroxydopamine. Thirty healthy female Sprague-Dawley
Heng Zhai, Zihua Kang, Haibo Zhang, Junjie Ma, Guangxin Chen   +4 more
doaj   +1 more source

Inhibition of CYP2E1 activities by baicalin.

, 2013
(A) Inhibition of CYP2E1 activities by baicalin in pooled rat liver microsomes, presented as percentage of control activities (the concentration of CZN is 50 µM).
Na Gao (137976), Hai-Ling Qiao (291010), Dan Zou (291008)   +2 more
core   +1 more source