Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
Analysis of biogas injera baking stove with modified circular ring burner and clay baking pan. [PDF]
Sci RepGeda TA, Ambie DA, Adem KD, Shetty RP.
europepmc +1 more source
Advanced Science, EarlyView.The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong +13 more
wiley +1 more source
Design optimization and experimental validation of a biogas-powered stove for energy efficiency in injera baking in rural Ethiopia. [PDF]
Sci RepSyum GG +5 more
europepmc +1 more source
Surface Plasmon Enhanced Photoluminescence of Carbon Dots Formed In Situ on Silver Gratings
Advanced Science, EarlyView.Carbon emitters formed in situ on a silver grating via plasmonic catalysis yield enhanced spontaneous emission by preferential radiative decay into surface plasmons. Enhancement manifests as emission exhibiting characteristics of coherence (polarization, directionality), and accelerated lifetimes of ∼30 ps, yielding Purcell factors of ∼70.
Maryam Sadat Amiri Naeini +5 more
wiley +1 more source
Temperature Resistant Evaluation of the Baking Processed Goods
Food Industry, 2018 A.L. Vereshchagin, N.V. Bychin
openaire +1 more source
Advanced Science, EarlyView.A deep comprehension of biomolecular phenomena at interfaces is significant with their fundamental and practical importance. Our experimental and theoretical investigations reveal that specific amino acids (glutamic acid and aspartic acid) exhibit an orientational coupling with liquid crystals, which can recognize and optically report the interfacial ...
Yena Choi +10 more
wiley +1 more source
The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models
Advanced Science, EarlyView.Direct‐current produces nerve lesioning through discrete electrochemical reactions. Using hypoxia‐sensitive locust nerves and hypoxia‐tolerant leech nerves, we map three injury pathways: cathodic oxygen reduction, cathodic alkalization, and anodic chloride oxidation. These findings establish electrochemical lesioning—the “Faraday Scalpel”—as a precise,
Petra Ondráčková +5 more
wiley +1 more source
Development of a Rice Bread Baking Method via Gelatinization Temperature Control Using Modified Starch. [PDF]
J Appl Glycosci (1999)Yano H +4 more
europepmc +1 more source
Fabrication of High‐Density Multimodal Neural Probes Based on Heterogeneously Integrated CMOS
Advanced Science, EarlyView.A chiplet‐based methodology democratizes active neural probe development on standard bulk CMOS services. This yields the first probe combining high‐density electrophysiology (416 electrodes) with calcium imaging (832 photodiodes) and complete on‐chip signal processing across 13 shanks.
Ju Hee Mun +10 more
wiley +1 more source