Results 71 to 80 of about 1,776 (195)

Primary amoebic meningoencephalitis: amoebicidal effects of clinically approved drugs against Naegleria fowleri [PDF]

, 2014
Here we tested the effects of clinically approved drugs targeting vital cellular receptors and biochemical pathways against Naegleria fowleri. For the first time, our findings revealed that digoxin and procyclidine showed potent amoebicidal effects as no
Baig, Abdul, Khan, Naveed A, Kulsoom, Huma   +2 more
core   +1 more source

Disseminated Infection with Balamuthia mandrillaris in a Dog [PDF]

Veterinary Pathology, 2004
Bilateral chronic granulomatous nephritis and meningoencephalitis were diagnosed on necropsy of a 2-year-old male Great Dane dog. The causative agent was identified as Balamuthia mandrillaris, based on morphologic features, immunohistochemical staining, and deoxyribonucleic acid detection using the polymerase chain reaction with newly designed primer ...
O, Foreman, J, Sykes, L, Ball, N, Yang, H, De Cock   +4 more
openaire   +2 more sources

Modelling dynamics between free‐living amoebae and bacteria

Environmental Microbiology, Volume 26, Issue 5, May 2024.
This review scrutinizes mathematical models designed to simulate the interactions between free‐living amoebae and bacteria. Identified gaps encompass (1) the necessity to tackle complexities such as spatial heterogeneity and population diversity; and (2) the essential understanding of the system.
Marwa Ali, Christopher A. Rice, Andrew W. Byrne, Philip E. Paré, Wendy Beauvais   +4 more
wiley   +1 more source

Encephalomyelomeningitis Caused by Balamuthia mandrillaris: A Case Report and Literature Review

Infection and Drug Resistance, 2023
XueMei Fan,1 TianWen Chen,1 Hui Yang,1 Yue Gao,2,* Yan Chen1,* 1Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of General ...
Fan X, Chen T, Yang H, Gao Y, Chen Y
doaj  

Future priorities in tackling infections due to brain-eating amoebae [PDF]

, 2017
Brain-eating amoebae (Acanthamoeba spp., Balamuthia mandrillaris and Naegleria fowleri) can cause opportunistic infections involving the central nervous system.
Anwar, Ayaz *, Khan, Naveed Ahmed *, Siddiqui, Ruqaiyyah Bano *   +2 more
core   +1 more source

Transmission ofBalamuthia mandrillarisby Organ Transplantation [PDF]

Clinical Infectious Diseases, 2016
During 2009 and 2010, 2 clusters of organ transplant-transmitted Balamuthia mandrillaris, a free-living ameba, were detected by recognition of severe unexpected illness in multiple recipients from the same donor.We investigated all recipients and the 2 donors through interview, medical record review, and testing of available specimens retrospectively ...
Eileen C, Farnon, Kenneth E, Kokko, Philip J, Budge, Chukwuma, Mbaeyi, Emily C, Lutterloh, Yvonne, Qvarnstrom, Alexandre J, da Silva, Wun-Ju, Shieh, Sharon L, Roy, Christopher D, Paddock, Rama, Sriram, Sherif R, Zaki, Govinda S, Visvesvara, Matthew J, Kuehnert, Joli, Weiss, Ken, Komatsu, Richard, Manch, Alberto, Ramos, Leonor, Echeverria, Ann, Moore, Phil, Zakowski, Michelle, Kittleson, Jon, Kobashigawa, Jonathan, Yoder, Michael, Beach, William, Mahle, Kirk, Kanter, P J, Geraghty, Eileen, Navarro, Christine, Hahn, Shiro, Fujita, Jim, Stinson, Joel, Trachtenberg, Paul, Byers, Michele, Cheung, Tun, Jie, Bruce, Kaplan, Rainer, Gruessner, Erica, Bracamonte, Chad, Viscusi, Regino, Gonzalez-Peralta, Robert, Lawrence, Jonathan, Fratkin, Fauzia, Butt   +43 more
openaire   +2 more sources

Glucose metabolism in the pathogenic free‐living amoebae: Tempting targets for treatment development

Chemical Biology &Drug Design, Volume 103, Issue 1, January 2024.
Enzymes involved in glucose metabolism may be promising therapeutic targets for drug development against the pathogenic free‐living amoebae. Details about the enzyme sequence and structural properties make a compelling case for designing small molecule inhibitors that are specific to the amoebae and would not affect the host enzyme.AbstractPathogenic ...
Jillian E. Milanes, Samuel Kwain, Allyson Drawdy, Laura Dodson, Matthew T. Monaghan, Christopher A. Rice, Brian N. Dominy, Daniel C. Whitehead, James C. Morris   +8 more
wiley   +1 more source

Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii

Pathogens, 2020
Pathogenic free-living amoebae, Balamuthia mandrillaris, Naegleria fowleri, and several Acanthamoeba species are the etiological agents of severe brain diseases, with case mortality rates > 90%.
Christopher A. Rice, Emma V. Troth, A. Cassiopeia Russell, Dennis E. Kyle   +3 more
doaj   +1 more source

Zinc Oxide Nanoconjugates against Brain-Eating Amoebae

Antibiotics, 2022
Naegleria fowleri and Balamuthia mandrillaris are opportunistic protists, responsible for fatal central nervous system infections such as primary amoebic meningoencephalitis (PAM) and granulomatous amoebic encephalitis (GAE) with mortality rates higher ...
Ruqaiyyah Siddiqui, Anania Boghossian, Noor Akbar, Tooba Jabri, Zara Aslam, Muhammad Raza Shah, Ahmad M. Alharbi, Hasan Alfahemi, Naveed Ahmed Khan   +8 more
doaj   +1 more source

Molecular Diagnosis of Encephalitis/Meningoencephalitis Caused by Free-Living Amoebae from a Tertiary Center in India

Pathogens, 2022
Background: Pathogenic free-living amoeba (FLA) such as Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris are causative agents of fatal amoebic encephalitis/meningoencephalitis.
Sumeeta Khurana, Chayan Sharma, Bishan Dass Radotra, Abhishek Mewara, Parveen Tanwar, Priya Datta, Rakesh Sehgal   +6 more
doaj   +1 more source