Results 61 to 70 of about 1,383 (171)

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

mBio, 2018
Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B.
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi   +9 more
doaj   +1 more source

Restoration ecology in conflict along the Colorado front range

Restoration Ecology, Volume 34, Issue 7, September 2026.
Abstract Introduction Cheatgrass (Bromus tectorum) is a challenge to restoration in western North America. It attracts the attention of academic and government research scientists, weed managers, and chemical companies. Attempts to control it cause conflicts among these groups.
G. Robert Brakenridge, Tim R. Seastedt
wiley   +1 more source

A Novel Protistan Trait Database Reveals Functional Redundancy and Complementarity in Terrestrial Protists (Amoebozoa and Rhizaria)

Molecular Ecology Resources, Volume 26, Issue 1, January 2026.
ABSTRACT The inclusion of functional traits of protists in environmental sequencing surveys, in addition to the traditional taxonomic framework, is essential for a better understanding of their roles and impacts on ecosystem processes. We provide a database of functional traits for a widespread and important clade of protists—the Amoebozoa—based on ...
Jule Freudenthal, Martin Schlegel, Michael Bonkowski, Kenneth Dumack   +3 more
wiley   +1 more source

Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy

Case Reports in Hematology, Volume 2018, Issue 1, 2018., 2018
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries. A common first‐line therapy offered to qualifying patients includes ibrutinib, an oral covalent inhibitor of Bruton’s tyrosine kinase. Treatment of CLL with ibrutinib therapy is generally well tolerated; however, serious opportunistic infections are being ...
Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah, Kiyotaka Kawauchi   +4 more
wiley   +1 more source

The first reported case of Balamuthia amoebic encephalitis initially presenting as anti-NMDAR encephalitis

Frontiers in Medicine
Balamuthia mandrillaris (B. mandrillaris) is a highly pathogenic free-living amoeba that can invade the central nervous system and cause Balamuthia amoebic encephalitis (BAE).
Shaoqing Yang, Zhijie Fan, Rui Wu, Lirong Duan, Jingjie Sun, Jingjie Sun   +5 more
doaj   +1 more source

In Vitro Activity of Nitroxoline (5‐Nitro‐8‐Hydroxyquinoline) Against Aspergillus Species

Mycoses, Volume 68, Issue 11, November 2025.
ABSTRACT Background Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc. Objectives As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against ...
Ada Hoffmann, Oliver A. Cornely, Jana Vonhoegen, Rosanne Sprute, Ilana Reinhold, Grit Walther, Frieder Fuchs, Michaela Simon   +7 more
wiley   +1 more source

sj-pdf-1-imr-10.1177_03000605221093217 - Supplemental material for Subacute Balamuthia mandrillaris encephalitis in an immunocompetent patient diagnosed by next-generation sequencing

, 2022
Supplemental material, sj-pdf-1-imr-10.1177_03000605221093217 for Subacute Balamuthia mandrillaris encephalitis in an immunocompetent patient diagnosed by next-generation sequencing by Changbo Xu, Xiaoyan Wu, Miaoqin Tan, Dongmei Wang, Shengnan Wang and ...
Miaoqin Tan (5681759), Dongmei Wang (282313), Shengnan Wang (398641), Xiaoyan Wu (235931), Changbo Xu (12505199), Yongming Wu (123327)   +5 more
core   +1 more source

Application of ventriculoscopy in granulomatous amoebic encephalitis: a case report in China and literature review

Frontiers in Medicine
Balamuthia mandrillaris is a kind of brain-eating amoeba leading to granulomatous amoebic encephalitis (GAE) with a high mortality rate and limited effective treatment options. Its underlying pathological mechanisms are still poorly understood.
Zequan Zheng, Zequan Zheng, Fajun Chen, Lulu Qin, Aili Lu, Haoyou Xu, Min Zhao, Yuanqi Zhao   +7 more
doaj   +1 more source

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

PLoS Neglected Tropical Diseases, 2020
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle   +4 more
doaj   +1 more source

Isolation and identification of free-living amoeba from contact lenses: Thermal and osmotic tolerance in relation to their pathogenicity. [PDF]

Assiut University Journal of Multidisciplinary Scientific Research, 2022
Free-living amoeba (FLA) such as Acanthamoeba spp., Naegleria fowleri, Balamuthia mandrillaris, and Sappinia diploidea are widely distributed natural and human-made environments which may cause human diseases.  For example, N.
doaj   +1 more source