Results 41 to 50 of about 493 (152)

Balamuthia mandrillaris trophozoites ingest human neuronal cells via a trogocytosis-independent mechanism

Parasites & Vectors, 2022
Background Environmental protozoa need an adaptation mechanism to survive drastic changes in niches in the human body. In the brain parenchyma, Balamuthia mandrillaris trophozoites, which are causative agents of fatal brain damage, must acquire nutrients
Worakamol Pengsart, Nongnat Tongkrajang, Narisara Whangviboonkij, Patsharaporn Techasintana Sarasombath, Kasem Kulkeaw   +4 more
doaj   +1 more source

Disseminated Infection with Balamuthia mandrillaris in a Dog [PDF]

Veterinary Pathology, 2004
Bilateral chronic granulomatous nephritis and meningoencephalitis were diagnosed on necropsy of a 2-year-old male Great Dane dog. The causative agent was identified as Balamuthia mandrillaris, based on morphologic features, immunohistochemical staining, and deoxyribonucleic acid detection using the polymerase chain reaction with newly designed primer ...
O, Foreman, J, Sykes, L, Ball, N, Yang, H, De Cock   +4 more
openaire   +2 more sources

Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells

, 2004
The first isolation in the UK of Balamuthia mandrillaris amoebae from a fatal case of granulomatous amoebic meningoencephalitis is reported. Using primary cultures of human brain microvascular endothelial cells (HBMECs), amoebae were isolated from the ...
Rogers, Claire, Alsam, S., Nolder, Debbie, Rogers, C., Sissons, J., Nolder, D., Jayasekera, S., Alsam, Selwa, Tucker, J., Warhurst, D., White, J.M.L., Jayasekera, Samantha, Higgins, E.M., Sissons, James, Higgins, EM, Khan, Naveed Ahmed, Warhurst, David, White, Jonathan ML, Tucker, Julie   +18 more
core   +1 more source

Transmission ofBalamuthia mandrillarisby Organ Transplantation [PDF]

Clinical Infectious Diseases, 2016
During 2009 and 2010, 2 clusters of organ transplant-transmitted Balamuthia mandrillaris, a free-living ameba, were detected by recognition of severe unexpected illness in multiple recipients from the same donor.We investigated all recipients and the 2 donors through interview, medical record review, and testing of available specimens retrospectively ...
Eileen C, Farnon, Kenneth E, Kokko, Philip J, Budge, Chukwuma, Mbaeyi, Emily C, Lutterloh, Yvonne, Qvarnstrom, Alexandre J, da Silva, Wun-Ju, Shieh, Sharon L, Roy, Christopher D, Paddock, Rama, Sriram, Sherif R, Zaki, Govinda S, Visvesvara, Matthew J, Kuehnert, Joli, Weiss, Ken, Komatsu, Richard, Manch, Alberto, Ramos, Leonor, Echeverria, Ann, Moore, Phil, Zakowski, Michelle, Kittleson, Jon, Kobashigawa, Jonathan, Yoder, Michael, Beach, William, Mahle, Kirk, Kanter, P J, Geraghty, Eileen, Navarro, Christine, Hahn, Shiro, Fujita, Jim, Stinson, Joel, Trachtenberg, Paul, Byers, Michele, Cheung, Tun, Jie, Bruce, Kaplan, Rainer, Gruessner, Erica, Bracamonte, Chad, Viscusi, Regino, Gonzalez-Peralta, Robert, Lawrence, Jonathan, Fratkin, Fauzia, Butt   +43 more
openaire   +2 more sources

Molecular analysis unmasking a Balamuthia mandrillaris: Skin lesion and granulomatous amebic encephalitis by Acanthamoeba sp close to genotype T4 with fatal outcome

Clinical Infection in Practice
Background: Acanthamoeba sp, Balamuthia mandrillaris, are a free-living soil amoeba, has emerged as a causative agent of chronic GAE. Methods: The nasal biopsy was sent to our Laboratory of Pathogenic Protozoa and Endosymbionts (LPEP).
Alfonso Martín Cabello-Vílchez, M. Isabel Ruiz-Ruiz   +1 more
doaj   +1 more source

Lethal encounters: The evolving spectrum of amoebic meningoencephalitis

IDCases, 2019
The free-living amoebae are thermophilic organisms that may play an increasing role among diseases of a warming world. They are uncommon, accidental, yet high consequence pathogens, with differing pathologic syndromes.
Sandra G. Gompf, Cristina Garcia
doaj   +1 more source

Functional annotation and comparative genomics analysis of Balamuthia mandrillaris reveals potential virulence-related genes

Scientific Reports, 2023
Balamuthia mandrillaris is a pathogenic protozoan that causes a rare but almost always fatal infection of the central nervous system and, in some cases, cutaneous lesions. Currently, the genomic data for this free-living amoeba include the description of
Alejandro Otero-Ruiz, Libia Zulema Rodriguez-Anaya, Fernando Lares-Villa, Luis Fernando Lozano Aguirre Beltrán, Luis Fernando Lares-Jiménez, Jose Reyes Gonzalez-Galaviz, Abraham Cruz-Mendívil   +6 more
doaj   +1 more source

Balamuthia mandrillarisexhibits metalloprotease activities [PDF]

FEMS Immunology & Medical Microbiology, 2006
Balamuthia mandrillaris is a recently identified protozoan pathogen that can cause fatal granulomatous encephalitis. However, the pathogenesis and pathophysiology of B. mandrillaris encephalitis remain unclear. Because proteases may play a role in the central nervous system (CNS) pathology, we used spectrophotometric, cytopathic and zymographic assays ...
Abdul, Matin, Monique, Stins, Kwang Sik, Kim, Naveed Ahmed, Khan   +3 more
openaire   +2 more sources

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

mBio, 2018
Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B.
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi   +9 more
doaj   +1 more source

Isolation and identification of free-living amoeba from contact lenses: Thermal and osmotic tolerance in relation to their pathogenicity. [PDF]

Assiut University Journal of Multidisciplinary Scientific Research, 2022
Free-living amoeba (FLA) such as Acanthamoeba spp., Naegleria fowleri, Balamuthia mandrillaris, and Sappinia diploidea are widely distributed natural and human-made environments which may cause human diseases.  For example, N.
doaj   +1 more source