Results 91 to 100 of about 1,513,785 (298)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Seeking Balance [PDF]

AAOHN Journal, 2010
This column is intended to offer a mini break from stress, and to be a gentle reminder to seek balance daily to ensure the nurse will be effective when needed.
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Research on graphic data formats for compact representation and comparison of images

Збірник наукових праць Державного університету інфраструктури та технологій: серія "Транспортні системи і технології"
This article investigates common methods of lossy and lossless compression of graphic information. The advantages and disadvantages of compression methods are identified as a result of the research.
Олександр Герцій
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Research and development of new variable compression ratio (VCR) engine mechanism (2nd Report, Dynamics analysis and vibration experiment of VCR engine mechanism)

Nihon Kikai Gakkai ronbunshu, 2019
In order to improve the efficiency of combustion engines, variable compression ratio (VCR) engine is researched. VCR engine changes the compression ratio according to its mechanical configuration. One of the solutions to construct VCR engine is the multi-
Sadatomo KURIBAYASHI, Hidenori KOMATSUBARA   +1 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An Accurate Deep Learning-Based Computer-Aided Diagnosis System for Gastrointestinal Disease Detection Using Wireless Capsule Endoscopy Image Analysis

Applied Sciences
Peptic ulcers and stomach cancer are common conditions that impact the gastrointestinal (GI) system. Wireless capsule endoscopy (WCE) has emerged as a widely used, noninvasive technique for diagnosing these issues, providing valuable insights through the
Sameh Abd El-Ghany, Mahmood A. Mahmood, A. A. Abd El-Aziz   +2 more
doaj   +1 more source