Results 31 to 40 of about 366,391 (138)

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig, Eamonn Kelly, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Alex C. Conner, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, Chandy George, Steve A. N. Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +72 more
wiley   +1 more source

Clinical findings and kidney morphology in chronic kidney disease of unknown cause in India

Journal of Internal Medicine, Volume 294, Issue 4, Page 492-505, October 2023., 2023
Abstract Background Chronic kidney disease of unknown cause (CKDu) is an emerging health problem in India and other countries worldwide. However, clinical descriptions, including kidney pathology, are scarce. Methods This is a descriptive case series of patients with CKDu from an endemic region in India, with a focus on clinical and biochemical ...
Julia Wijkström, Kumar Chakravarthy Annadata, Carl‐Gustaf Elinder, Praveen Kumar Kolla, Narayana Rao Sarvepalli, Anneli Ring, Rajendiran Swaminathan, Barathi Gunabooshanam, Magnus Söderberg, Vidhya Venugopal, Annika Wernerson   +10 more
wiley   +1 more source

Chronic kidney disease of unknown aetiology: A comprehensive review of a global public health problem

Tropical Medicine &International Health, Volume 28, Issue 8, Page 588-600, August 2023., 2023
Abstract The term chronic kidney disease of unknown aetiology (CKDu) refers to chronic kidney disease (CKD) in the absence of diabetes, long‐standing hypertension, glomerulonephritis, obstructive uropathy or other apparent causes. An increasing number of CKDu cases have been reported from Latin America, Sri Lanka, India and others over the last two ...
Indu Ramachandra Rao, Ashika Bangera, Shankar Prasad Nagaraju, Srinivas Vinayak Shenoy, Ravindra Attur Prabhu, Dharshan Rangaswamy, Mohan Varadanayakanahalli Bhojaraja   +6 more
wiley   +1 more source

Occurrence, identification, and decontamination of potential mycotoxins in fruits and fruit by‐products

Food Frontiers, Volume 4, Issue 1, Page 32-46, March 2023., 2023
Graphical Abstract: Abstract The incidence of aflatoxins, ochratoxin A, and patulin in fruits and processed fruit products has been ever more challenging and gained additional focus on ecofriendly mitigation strategies. The onset of these toxins is due to several factors involving insect attacks, agricultural practices, and climate change.
Karthika Pushparaj, Arun Meyyazhagan, Manikantan Pappuswamy, Amin Mousavi Khaneghah, Wen‐Chao Liu, Balamuralikrishnan Balasubramanian   +5 more
wiley   +1 more source

Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2012
Introduction. Balkan endemic nephropathy (BEN) patients maintained with hemodialysis have more severe anemia than patients with other kidney diseases. Objective.
Lukić Ljiljana, Mitrović Đorđe, Kovačević Sanda, Stanišić Momir, Pelemiš Snežana, Tešić Jelica, Vakičić Slaven, Đukanović Ljubica   +7 more
doaj   +1 more source

Prevalence and risk factors of vascular calcification in pre-dialysis patients with Balkan endemic nephropathy [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2016
Introduction. Vascular calcifications (VC) are common in patients with chronic kidney disease and present one of manifestations of mineral and bone disorders in these patients. Objective. The aim of this pilot study was to examine the prevalence
Petković Nenad, Marić Radmil, Gajanin Radoslav, Batinić Danijela, Ćuk Mirjana, Ristić Siniša, Đukanović Ljubica   +6 more
doaj   +1 more source

Aristolochic acid I induces proximal tubule injury through ROS/HMGB1/mt DNA mediated activation of TLRs

Journal of Cellular and Molecular Medicine, Volume 26, Issue 15, Page 4277-4291, August 2022., 2022
Abstract Aristolochic acids (AAs) are extracted from certain plants as folk remedies for centuries until their nephrotoxicity and carcinogenicity were recognized. Aristolochic acid I (AAI) is one of the main pathogenic compounds, and it has nephrotoxic, carcinogenic and mutagenic effects.
Rohit Upadhyay, Vecihi Batuman
wiley   +1 more source

Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA [PDF]

, 2010
Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jennings-Gee, Jamie E., Mark Steven Miller, Tozlovanu, Mariana, Jamie E. Jennings-Gee, Mariana Tozlovanu, Miller, Mark Steven, Annie Pfohl-Leszkowicz, Gary G. Schwartz, Schwartz, Gary G., Manderville, Richard A., Pfohl-Leszkowicz, Annie, Richard Manderville   +11 more
core   +1 more source

Two decades of chronic kidney disease of unknown aetiology (CKDu) research: Existing evidence and persistent gaps from epidemiological studies in Sri Lanka

Nephrology, Volume 27, Issue 3, Page 238-247, March 2022., 2022
Abstract Background Chronic Kidney Disease of unknown origin (CKDu) excludes known primary renal conditions or systemic disease (such as diabetes mellitus or hypertension). Prominence of CKDu has been noted for some decades in Sri Lanka, especially among men in particular rural areas, prompting many studies directed towards environmental causation ...
Jennifer Pett, Fahim Mohamed, John Knight, Christine Linhart, Nicholas J. Osborne, Richard Taylor   +5 more
wiley   +1 more source

Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure

International Journal of Cancer, Volume 150, Issue 2, Page 374-386, 15 January 2022., 2022
Abstract Recurrent upper tract urothelial carcinomas (UTUCs) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe.
Sandra Karanović, Maude Ardin, Zuojian Tang, Karla Tomić, Stephanie Villar, Claire Renard, Elisa Venturini, Adam H. Lorch, Daniel S. Lee, Želimir Stipančić, Neda Slade, Ivana Vuković Brinar, Damir Dittrich, Krešimir Karlović, Fran Borovečki, Kathleen G. Dickman, Magali Olivier, Arthur P. Grollman, Bojan Jelaković, Jiri Zavadil   +19 more
wiley   +1 more source