Results 41 to 50 of about 1,327 (186)

Higher dose of erythropoietin for anemia correction in Balkan endemic nephropathy patients [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2012
Introduction. Balkan endemic nephropathy (BEN) patients maintained with hemodialysis have more severe anemia than patients with other kidney diseases. Objective.
Lukić Ljiljana, Mitrović Đorđe, Kovačević Sanda, Stanišić Momir, Pelemiš Snežana, Tešić Jelica, Vakičić Slaven, Đukanović Ljubica   +7 more
doaj   +1 more source

Aristolochic acid I induces proximal tubule injury through ROS/HMGB1/mt DNA mediated activation of TLRs

Journal of Cellular and Molecular Medicine, Volume 26, Issue 15, Page 4277-4291, August 2022., 2022
Abstract Aristolochic acids (AAs) are extracted from certain plants as folk remedies for centuries until their nephrotoxicity and carcinogenicity were recognized. Aristolochic acid I (AAI) is one of the main pathogenic compounds, and it has nephrotoxic, carcinogenic and mutagenic effects.
Rohit Upadhyay, Vecihi Batuman
wiley   +1 more source

Prevalence and risk factors of vascular calcification in pre-dialysis patients with Balkan endemic nephropathy [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2016
Introduction. Vascular calcifications (VC) are common in patients with chronic kidney disease and present one of manifestations of mineral and bone disorders in these patients. Objective. The aim of this pilot study was to examine the prevalence
Petković Nenad, Marić Radmil, Gajanin Radoslav, Batinić Danijela, Ćuk Mirjana, Ristić Siniša, Đukanović Ljubica   +6 more
doaj   +1 more source

Two decades of chronic kidney disease of unknown aetiology (CKDu) research: Existing evidence and persistent gaps from epidemiological studies in Sri Lanka

Nephrology, Volume 27, Issue 3, Page 238-247, March 2022., 2022
Abstract Background Chronic Kidney Disease of unknown origin (CKDu) excludes known primary renal conditions or systemic disease (such as diabetes mellitus or hypertension). Prominence of CKDu has been noted for some decades in Sri Lanka, especially among men in particular rural areas, prompting many studies directed towards environmental causation ...
Jennifer Pett, Fahim Mohamed, John Knight, Christine Linhart, Nicholas J. Osborne, Richard Taylor   +5 more
wiley   +1 more source

Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure

International Journal of Cancer, Volume 150, Issue 2, Page 374-386, 15 January 2022., 2022
Abstract Recurrent upper tract urothelial carcinomas (UTUCs) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe.
Sandra Karanović, Maude Ardin, Zuojian Tang, Karla Tomić, Stephanie Villar, Claire Renard, Elisa Venturini, Adam H. Lorch, Daniel S. Lee, Želimir Stipančić, Neda Slade, Ivana Vuković Brinar, Damir Dittrich, Krešimir Karlović, Fran Borovečki, Kathleen G. Dickman, Magali Olivier, Arthur P. Grollman, Bojan Jelaković, Jiri Zavadil   +19 more
wiley   +1 more source

Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA [PDF]

, 2010
Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jennings-Gee, Jamie E., Mark Steven Miller, Tozlovanu, Mariana, Jamie E. Jennings-Gee, Mariana Tozlovanu, Miller, Mark Steven, Annie Pfohl-Leszkowicz, Gary G. Schwartz, Schwartz, Gary G., Manderville, Richard A., Pfohl-Leszkowicz, Annie, Richard Manderville   +11 more
core   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

British Journal of Pharmacology, Volume 178, Issue S1, Page S157-S245, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Alistair Mathie, John A Peters, Emma L Veale, Jörg Striessnig, Eamonn Kelly, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Richard W. Aldrich, Bernard Attali, Austin M Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, William A. Catterall, Alex C. Conner, Paul Davies, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Chandy George, Steve A. N. Goldstein, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Mike Jarvis, Anders A. Jensen, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Joseph W. Lynch, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Lixia Yue, Xiaoli Zhang, Michael Zhu   +57 more
wiley   +1 more source

Ochratoxin A: 50 Years of Research

Toxins, 2016
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health.
Frantisek Malir, Vladimir Ostry, Annie Pfohl-Leszkowicz, Jan Malir, Jakub Toman   +4 more
doaj   +1 more source

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy

FEBS Open Bio, Volume 11, Issue 2, Page 507-518, February 2021., 2021
We investigated the activity of xanthine oxidoreductase (XOR) in a mouse model of aristolochic acid I (AA)‐induced nephropathy, a type of chronic kidney disease (CKD). After 4 weeks of AA (2.5 mg·kg−1) administration, renal histology revealed an increase in tubular interstitial fibrosis and XOR activity was persistently increased in renal tissue.
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura   +13 more
wiley   +1 more source

Simultaneous ipsilateral rhabdoid renal cell carcinoma and multifocal urothelial carcinoma of the ureter in a patient from the region of Balkan endemic nephropathy: Case report and literature review [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2021
Introduction. Simultaneous ipsilateral coexistence of renal cell carcinoma (RCC) and upper urinary tract urothelial carcinoma (UTUC) rarely occurs. Balkan endemic nephropathy (BEN) is a chronic degenerative tubulointerstitial renal disease, strongly ...
Bašić Dragoslav, Janković-Veličković Ljubinka, Ignjatović Ivan, Hadži-Đokić Jovan, Veljković Andrej   +4 more
doaj   +1 more source