Results 71 to 80 of about 1,592 (202)

Aspergillus Mycotoxins: The Major Food Contaminants

Advanced Science, Volume 12, Issue 9, March 6, 2025.
Mycotoxins produced by Aspergillus contaminate food products and threat to human health. The multifaceted biosynthesis pathways are first discussed and elucidated several global regulators of the mycotoxins in detail. How global shifts in temperature and water availability, driven by climate change, are key determinants of Aspergillus proliferation and
Mengyao Xue, Zheng Qu, Antonio Moretti, Antonio F. Logrieco, Haiyan Chu, Qi Zhang, Changpo Sun, Xianfeng Ren, Li Cui, Qinglin Chen, Yi An, Chengjun Li, Huan Zhong, Zhiyan Cao, Feng Wang, Yuebing Sun, Lili Wang, Jie Hou, Chenchen Zhang, Mengmeng Yang, Yiming Ding, Yanpo Yao, Peiwu Li, Yong‐Guan Zhu   +23 more
wiley   +1 more source

The Role of Inflammation, Oxidative Stress, Neuronal Damage, and Endothelial Dysfunction in the Neuropathology of Cognitive Complications in Diabetes: A Moderation and Mediation Analysis

Brain and Behavior, Volume 15, Issue 1, January 2025.
ABSTRACT Objective Cognitive impairment is increasingly recognized as a complication of diabetes, yet the underlying pathology remains unclear. This study aims to investigate the roles of inflammation, oxidative stress, endothelial dysfunction, and neuronal damage in the neuropathology underlying diabetes related cognitive impairment.
Betul Sumbul‐Sekerci, Ozge Pasin, Ezgi Balkan, Abdusselam Sekerci   +3 more
wiley   +1 more source

Comparative 1H NMR Metabolomic Urinalysis of People Diagnosed with Balkan Endemic Nephropathy, and Healthy Subjects, in Romania and Bulgaria: A Pilot Study

Toxins, 2011
1H NMR spectroscopy of urine has been applied to exploring metabolomic differences between people diagnosed with Balkan endemic nephropathy (BEN), and treated by haemodialysis, and those without overt renal disease in Romania and Bulgaria.
Draga Toncheva, Diana Tatu, Calin Tatu, Andrew Nicholls, Mirela Modalca, Peter Mantle   +5 more
doaj   +1 more source

Aristolochic acid‐related renal cell carcinoma exhibits a distinct tumor‐immune microenvironment favoring response to immune checkpoint blockade

The Journal of Pathology, Volume 264, Issue 4, Page 371-382, December 2024.
Abstract Immune checkpoint blockade (ICB) is currently the standard of care for metastatic renal cell carcinoma (RCC), but treatment responses remain unpredictable. Aristolochic acid (AA), a prevalent supplement additive in Taiwan, has been associated with RCC and induces signature mutations, although its effect on the tumor‐immune microenvironment ...
Po‐Hung Lin, Jason Yongsheng Chan, Peiyong Guan, Jing Han Hong, Abner Herbert Lim, Cedric Chuan‐Young Ng, Joe Poh Sheng Yeong, Jing Yi Lee, Wei Liu, Jeffrey Chun Tatt Lim, See‐Tong Pang, Bin Tean Teh   +11 more
wiley   +1 more source

Association of SOD2 (rs4880) and GPX1 (rs1050450) Gene Polymorphisms with Risk of Balkan Endemic Nephropathy and its Related Tumors

Medicina, 2019
Background and Objectives: Experimental data show that superoxide dismutase 2 (SOD2) is involved in ochratoxin (OTA)-induced nephrotoxicity, whereas clinical data indicate the role of SOD2 rs4880 or glutathione peroxidase 1 (GPX1) rs1050450 polymorphisms
Biljana Dragicevic, Sonja Suvakov, Djurdja Jerotic, Zorica Reljic, Ljubica Djukanovic, Ivanka Zelen, Marija Pljesa-Ercegovac, Ana Savic-Radojevic, Tatjana Simic, Dejan Dragicevic, Marija Matic   +10 more
doaj   +1 more source

Prevalence and concentration of Ochratoxin A in beer: A global systematic review, meta‐analysis, and health risk assessment

Food Science &Nutrition, Volume 12, Issue 11, Page 8503-8514, November 2024.
In the current study, levels and prevalence of Ochratoxin A (OTA) in beer were meta‐analyzed and non‐carcinogenic risk was calculated by the target hazard quotient. Thirty papers with 70 data reports were included in our study. The pooled prevalence of OTA was 50.60%, 95% CI (confidence interval) (36.97–64.19). Five countries with the highest levels of
Yadolah Fakhri, Vahid Ranaei, Zahra Pilevar, Olga F. Belaia, Natalia V. Kolaeva, Mansour Sarafraz, Amin Mousavi Khaneghah   +6 more
wiley   +1 more source

Does ochratoxin A (OTA) cause testicular cancer in humans?

Acta Medica Lituanica, 2011
Ochratoxin A (OTA) is a naturally occurring contaminant of cereals, pigmeat, and other foods and is a known genotoxic in animals. It is a nephrotoxin and a carcinogen associated with Balkan endemic nephropathy and urinary tract tumours.
Jayachandra SRINIVASA
doaj   +1 more source

TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma

The Kaohsiung Journal of Medical Sciences, Volume 40, Issue 3, Page 269-279, March 2024.
Abstract Urothelial carcinoma (UC) is common cancer worldwide with a high prevalence in Taiwan, especially in the upper urinary tract, including the renal pelvis and ureter, also classifying as upper urinary tract urothelial carcinoma. Here, we aim to find a representative prognostic marker that strongly correlates to this type of carcinoma ...
Peir‐In Liang, Yu‐Ching Wei, Huan‐Da Chen, Yu‐Chun Ma, Hung‐Lung Ke, Chu‐Chun Chien, Hao‐Wen Chuang   +6 more
wiley   +1 more source

Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms

, 2018
Aristolochic acid released from decaying Aristolochia clematitis weed is contaminating soil and food crops in Eastern Europe and is one of the major causes to Balkan endemic nephropathy.
Pavlović, Nikola M., Chi-Kong Chan, Yushuo Liu, Nikola M. Pavlović, Wan Chan, Liu, Yushuo, Chan, Chi Kong, Chan, Wan   +7 more
core   +1 more source

Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy

, 2020
Aristolochic acids (AAs) have been known as potent nephrotoxins since the use of AA-containing herbal medicines was linked with a series of sporadic renal fibrotic nephropathy cases, and yet an estimated 100 million people worldwide are still at risk ...
Pavlović, Nikola M., Chan, Kwan Kit Jason, Liu, Guorui, Tung, Ka Ki, Zhao, Yao, Chan, Chi Kong, Chan, Wan   +6 more
core   +1 more source