Results 51 to 60 of about 1,591 (203)

Optimization of bioactive compounds extraction from Rosa canina L. pseudofruit through the action of two hydrolytic enzyme preparations

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKROUND The pseudo‐fruit of Rosa canina L. is a rich source of bioactive compounds with antioxidant, anti‐inflammatory, anti‐cancer, anti‐diabetic, anti‐aging, and antimicrobial activities. The aim of the present study is the optimization of a green process based on the action of two hydrolytic enzyme preparations, namely Pectinex® Ultra ...
Zafeiria Lemoni, Styliani Kalantzi, Theopisti Lymperopoulou, Andromachi Tzani, Georgios Stavropoulos, Anastasia Detsi, Diomi Mamma   +6 more
wiley   +1 more source

Revealing a Pre-neoplastic Renal Tubular Lesion by p-S6 Protein Immunohistochemistry after Rat Exposure to Aristolochic Acid

Journal of Kidney Cancer and VHL, 2015
Aristolochic acid (AA) has, in the last decade, become widely promoted as the cause of the Balkan endemic nephropathy and associated renal or urothelial tumours, although without substantial focal evidence of the quantitative dietary exposure via bread ...
Alexandra Gruia, Patrycja Gazinska, Diana Herman, Valentin Ordodi, Calin Tatu, Peter George Mantle   +5 more
doaj   +1 more source

Rat Tumour Histopathology Associated with Experimental Chronic Dietary Exposure to Ochratoxin A in Prediction of the Mycotoxin’s Risk for Human Cancers

Toxins, 2021
Mammalian animal toxicity of ochratoxin A (OTA) has focused largely in the past half-century on pigs because of initial recognition of it as a principal cause of intermittent growth suppression and renal disease caused by mouldy feed.
Diana Herman, Peter Mantle
doaj   +1 more source

Evaluating the combined toxicity of Penicillium mycotoxins in absorption, metabolism, and excretion systems

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Penicillium mycotoxins, including ochratoxin A (OTA), citrinin (CIT), and cyclopiazonic acid (CPZ), frequently co‐occur in food commodities, contributing to chronic low‐level dietary exposure. However, current risk assessments often consider these toxins individually, overlooking potential interaction effects.
Carolina Sousa Monteiro, Eugénia Pinto, Miguel A Faria, Sara C Cunha   +3 more
wiley   +1 more source

Structural and functional characteristics of urinary tract in offspring of Balkan endemic nephropathy patients [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. Balkan endemic nephropathy (BEN) is a familial chronic progressive tubulointerstitial disease of unknown aetiology that occurs with high prevalence in endemic rural environments of Serbia, Bosnia and Herzegovina, Croatia, Bulgaria and ...
Radisavljević Snežana, Peco-Antić Amira, Kotur-Stevuljević Jelena, Savić Olivera   +3 more
doaj   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

GPX3 rs8177412 Polymorphism Modifies Risk of Upper Urothelial Tumors in Patients with Balkan Endemic Nephropathy

Medicina, 2023
Current data suggest that aristolochic acid (AA) exposure is a putative cause of Balkan endemic nephropathy (BEN), a chronic kidney disease strongly associated with upper tract urothelial carcinoma.
Zana Radic Savic, Vesna Coric, Stojko Vidovic, Vanja Vidovic, Jelena Becarevic, Irina Milovac, Zorica Reljic, Bosa Mirjanic-Azaric, Ranko Skrbic, Radoslav Gajanin, Marija Matic, Tatjana Simic   +11 more
doaj   +1 more source

NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy [PDF]

, 2014
Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression leading to terminal renal failure. The results of molecular biological investigations propose that BEN is a multifactorial disease
Karachanak, S., Dimova, I., Toncheva, D., Plaseska-Karanfilska, D., Dimitrov, P., Ivanov, S., Galabov, A., Staneva, R., Jankovic-Velickovic, L., Jevtovic-Stoimenov, T., Stefanovic, V., Balabanski, L., Vazharova, R., Cukuranović, R., Polenakovic, M., Simeonov, V., Serbezov, D., Malinov, M., Djonov, V., Mihailova-Hristova, M., Djordjevic, V.   +20 more
core   +1 more source

Aflatoxin B1, B2, G1, G2, Zearalenone, and Ochratoxin A in Cereals, Cereal‐Based Products and Baby Food: Method Validation, Monitoring Study and Exposure Assessment of the Italian Population

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
A validated HPLC‐FLD analytical method for the determination of aflatoxins, zearalenone, and ochratoxin A in cereals was applied to the analysis of 402 samples collected in Italy from 2013 to 2023 and to perform a risk assessment evaluation for the Italian population. Prevalence of contaminated samples was generally low and restricted to maize samples.
Stefano Sdogati, Serenella Orsini, Rita Bibi, Angela Caporali, Tommaso Pacini, Emanuela Verdini, Teresa D'Amore, Ivan Pecorelli   +7 more
wiley   +1 more source

Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN)

BMC Medical Genetics, 2012
Background Balkan Endemic Nephropathy (BEN) is late-onset kidney disease thought to arise from chronic exposure to aristolochic acid, a phytotoxin that contaminates wheat supplies in rural areas of Eastern Europe.
Wooding Stephen P, Atanasova Srebrena, Gunn Howard C, Staneva Rada, Dimova Invanka, Toncheva Draga   +5 more
doaj   +1 more source