Results 91 to 100 of about 128,512 (289)
Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis
eLife, 2020 The outer-membrane of Gram-negative bacteria is critical for surface adhesion, pathogenicity, antibiotic resistance and survival. The major constituent – hydrophobic β-barrel Outer-Membrane Proteins (OMPs) – are first secreted across the inner-membrane ...
Sara Alvira +11 more
doaj +1 more source
Kronos: a workflow assembler for genome analytics and informatics. [PDF]
, 2017 BackgroundThe field of next-generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized.
Aniba, Radhouane +9 more
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Targeting BAM for Novel Therapeutics against Pathogenic Gram-Negative Bacteria
Antibiotics, 2023 The growing emergence of multidrug resistance in bacterial pathogens is an immediate threat to human health worldwide. Unfortunately, there has not been a matching increase in the discovery of new antibiotics to combat this alarming trend.
Claire Overly Cottom +3 more
doaj +1 more source
The evolution of new lipoprotein subunits of the bacterial outer membrane BAM complex
Molecular Microbiology, 2012 SummaryThe β‐barrel assembly machine (BAM) complex is an essential feature of all bacteria with an outer membrane. The core subunit of the BAM complex is BamA and, in Escherichia coli, four lipoprotein subunits: BamB, BamC, BamD and BamE, also function in the BAM complex.
Anwari, Khatira +11 more
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Cell Reports, 2018 The β-barrel assembly machinery (BAM) complex is essential for localization of surface proteins on bacterial cells, but the mechanism by which it functions is unclear.
Sachith D. Gunasinghe +13 more
doaj +1 more source
Tensile & shear strength of porous dust agglomerates
, 2013 Context.Within the sequential accretion scenario of planet formation, planets are build up through a sequence sticking collisions. The outcome of collisions between porous dust aggregates is very important for the growth from very small dust particles to
Kley, Wilhelm +2 more
core +1 more source
The delivery complex in outer membrane protein biogenesis: How the SurA chaperone interacts with the BAM enzyme [PDF]
, 2023 Jim E. Horne +4 more
openalex +1 more source