Results 71 to 80 of about 2,709,660 (260)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Band Edge Dynamics and Multiexciton Generation in Narrow Band Gap HgTe Nanocrystals

, 2018
International audienceMercury chalcogenide nanocrystals and especially HgTe appear as an interesting platform for the design of low cost mid-infrared (mid-IR) detectors.
Ithurria, Sandrine, Amardeep Jagtap, Junling Qu, Martinez, Bertille, Lhuillier, Emmanuel, Qu, Junling, Livache, Clément, Nicolas Goubet, Clément Livache, Silly, Mathieu, Jagtap, Amardeep, Goubet, Nicolas, Sandrine Ithurria, Emmanuel Lhuillier, Mathieu G. Silly, Bertille Martinez, Benoit Dubertret, Dubertret, Benoit   +17 more
core   +1 more source

High-Efficiency Sub-100 nm Gate GaN HEMTs Enabled by Two-Step SiN_x Layer Etching Technique

Micromachines
This paper proposed a high-efficiency thin-barrier gallium nitride (GaN) high electron mobility transistor (HEMT) with scaled gate-length (Lg) for millimeter-wave (mmW) frequency applications.
Xiangxin Cao, Pengfei Wang, Minhan Mi, Xinyu Liu, Dongxu Xiao, Xiang Du, Maoteng Lu, Feiyang Chen, Zhentong Huang, Jingyun Yao, Yinyin Liang, Kehui Cui, Xiaohua Ma, Yue Hao   +13 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Nanocrystal-Embedded-Insulator (NEI) Ferroelectric FETs for Negative Capacitance Device and Non-Volatile Memory Applications

Nanoscale Research Letters, 2019
We report a novel nanocrystal-embedded-insulator (NEI) ferroelectric field-effect transistor (FeFET) with very thin unified-ferroelectric/dielectric (FE/DE) insulating layer, which is promising for low-voltage logic and non-volatile memory (NVM ...
Yue Peng, Genquan Han, Wenwu Xiao, Jibao Wu, Yan Liu, Jincheng Zhang, Yue Hao   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Band-Gap Bowing Parameter of the AlxIn1-xN Derived from Theoretical Simulation

, 2012
[[abstract]]The band-gap energy and band-gap bowing parameter of the wurtzite AlInN alloys are investigated numerically with the CASTEP simulation program. The simulation results suggest that the unstrained band-gap bowing parameter of the wurtzite AlInN
Kuo, Yen-Kuang; Lin, Wen-Wei
core  

The Study of Electrical Properties for Multilayer La2O3/Al2O3 Dielectric Stacks and LaAlO3 Dielectric Film Deposited by ALD

Nanoscale Research Letters, 2017
The capacitance and leakage current properties of multilayer La2O3/Al2O3 dielectric stacks and LaAlO3 dielectric film are investigated in this paper. A clear promotion of capacitance properties is observed for multilayer La2O3/Al2O3 stacks after post ...
Xing-Yao Feng, Hong-Xia Liu, Xing Wang, Lu Zhao, Chen-Xi Fei, He-Lei Liu   +5 more
doaj   +1 more source

Investigation of threshold voltage shift and gate leakage mechanisms in normally off AlN/Al0.05Ga0.95N HEMTs on Si substrate

AIP Advances, 2020
In this study, normally off AlN/Al0.05Ga0.95N high-electron-mobility transistors (HEMTs) on a Si substrate were fabricated by adjusting the surface states of the heterostructure.
Weihang Zhang, Xi Liu, Liyu Fu, Jincheng Zhang, Shenglei Zhao, Yue Hao   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source