Northeastern China, a Hotspot for Tick-Borne Viral Diseases [PDF]
Northeastern China has a high incidence of tick-borne diseases. Emerging and re-emerging tick-borne viral diseases pose a considerable threat to public health.
Zedong Wang, Ziyan Liu
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Molecular TherapySevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen endemic to East Asia, associated with high mortality and lacking approved vaccines or therapies. We developed a live-attenuated vaccine platform based on a recombinant SFTSV, which lacks the nonstructural protein on the S segment (NSs) gene, a key virulence ...
Ro, Hyo-Jin +17 more
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Fibrinogen-to-prealbumin and C-reactive protein-to-prealbumin ratios as prognostic indicators in severe fever with thrombocytopenia syndrome [PDF]
BackgroundThe primary aim of this study is to investigate the correlation between serum levels of fibrinogen-to-prealbumin ratio (FPR) and C-reactive protein-to-prealbumin ratio (CPR) and prognostic outcomes among patients with severe fever with ...
Fan Zhang +3 more
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mBioABSTRACT Oropouche virus (OROV), Rift Valley fever virus (RVFV), and Dabie bandavirus (DBV) are significant re-emerging and emerging human pathogens with major public health implications. Notably, the ongoing OROV disease epidemic spanning South America, Central America, and the Caribbean now exceeds 11,000 cases ...
Jonna B. Westover +10 more
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Ecological overview of hard ticks (Ixodida: Ixodidae) in Nagasaki prefecture of western Japan during winter 2021–2022 [PDF]
In Japan, Japanese spotted fever, Lyme disease and severe fever with thrombocytopenia syndrome caused by Ixodidae species are endemic. To prevent and control the diseases, fundamental understandings in tick ecology are crucial. Hence, this study aimed to
Hoshi, Tomonori +3 more
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SNX11-Deletion Inhibit Dabie Bandavirus Infection by Interfering with the Synthesis of V-ATPase
SNX11, a sorting nexin protein localized on the endosomal membrane, is an important protein closely related to protein sorting and endosomal trafficking. Previously, through a genome-wide CRISPR screening, we identified SNX11 as a critical protein for the entry of Dabie bandavirus.
Tiezhu Liu +6 more
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Engineering Viral Proteins for Use as Immune Response Suppressors [PDF]
, 2021 Winebrake, Katherine
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Trends in the incidence of severe fever with thrombocytopenia syndrome in Japan: an observational study from 2013 to 2022 [PDF]
We aimed to determine the 10-year trend in the incidence of Severe fever with thrombocytopenia syndrome (SFTS) in Japan. This retrospective observational study used a publicly available national database.
Akazawa, Hidemasa +3 more
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Machine learning for identifying risk of death in patients with severe fever with thrombocytopenia syndrome [PDF]
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) has attracted attention due to the rising incidence and high severity and mortality rates. This study aims to construct a machine learning (ML) model to identify SFTS patients at high risk of ...
Jiale Guo +4 more
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Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study [PDF]
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease characterized by rapid progression and high mortality.
Baoju Wang +16 more
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