Results 161 to 170 of about 13,919 (205)
BAP1: Not Just a BRCA1-Associated Protein [PDF]
Cancer Treatment Reviews, 2020 BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate a number of processes including DNA damage repair, cell cycle control, chromatin modification, programmed cell death, and the immune response.
Bryan H Louie, Razelle Kurzrock
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BAP1‐inactivated melanocytic tumor with preserved BAP1 expression? Morphology to the rescue!
Journal of Cutaneous Pathology, 2020AbstractBAP1‐inactivated melanocytic tumors typically present with distinctive histopathological changes and loss of nuclear BAP1 protein expression. Rare cases exhibit the typical morphology but with preserved expression of BAP1. In the current issue of Journal of Cutaneous Pathology, Linos et al.
Lyn M. Duncan, Michael T. Tetzlaff
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BAP1 Forms a Trimer With HMGB1 and HDAC1 That Modulates Gene × Environment Interaction With Asbestos
Proceedings of the National Academy of Sciences of the United States of America, 2021 Carriers of heterozygous germline BAP1 mutations (BAP1+/-) are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma.
Paolo Pinton +2 more
exaly +2 more sources
Tumours Associated With BAP1 Mutations
Pathology, 2013BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway.
Thomas Wiesner +2 more
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The American Journal of Dermatopathology, 2022
Abstract: BAP1-inactivated melanocytic tumors represent a subset of epithelioid melanocytic neoplasms resulting from biallelic inactivation of the BAP1 gene and by a driver mutation that activate the MAP kinase pathway, most commonly BRAF V600E
Michele Donati +2 more
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Abstract: BAP1-inactivated melanocytic tumors represent a subset of epithelioid melanocytic neoplasms resulting from biallelic inactivation of the BAP1 gene and by a driver mutation that activate the MAP kinase pathway, most commonly BRAF V600E
Michele Donati +2 more
openaire +2 more sources
Families With BAP1-Tumor Predisposition Syndrome in the Netherlands: Path to Identification and a Proposal for Genetic Screening Guidelines [PDF]
Cancers, 2019 Germline pathogenic variants in the BRCA1-associated protein-1 (BAP1) gene cause the BAP1-tumor predisposition syndrome (BAP1-TPDS, OMIM 614327). BAP1-TPDS is associated with an increased risk of developing uveal melanoma (UM), cutaneous melanoma (CM ...
Natasha M van Poppelen +2 more
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Familial Cancer, 2005
BAP1 whose protein interacts with BRCA1 was analysed in a series of 47 French familial breast cancer cases negatively tested for BRCA1/2 mutations. The lack of detection of deleterious mutations suggests that BAP1 is not a high risk breast cancer predisposing gene.
Isabelle, Coupier +6 more
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BAP1 whose protein interacts with BRCA1 was analysed in a series of 47 French familial breast cancer cases negatively tested for BRCA1/2 mutations. The lack of detection of deleterious mutations suggests that BAP1 is not a high risk breast cancer predisposing gene.
Isabelle, Coupier +6 more
openaire +2 more sources
Abstract 446: BAP1 mutation in mesothelioma and “BAP1 Cancer Syndrome”
Cancer Research, 2014Abstract Malignant mesothelioma (MM) is a lethal cancer whose pathogenesis results from complex interactions between host genetics and environmental carcinogens, such as asbestos and erionite fibers. Recently, BAP1 (BRCA associated protein 1) has been identified as a novel MM tumor suppressor gene located at 3p21, a region frequently ...
Masaki Nasu +10 more
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BAP1 Regulates IP3R3-Mediated Ca2+ Flux to Mitochondria Suppressing Cell Transformation [PDF]
Nature, 2017 BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1 +/-) developed one and often several BAP1 -/- malignancies
Paolo Pinton +2 more
exaly +2 more sources
Journal of Clinical Pathology, 2016
The BAP1 gene (BRCA1-associated protein 1) is a tumour suppressor gene that encodes a deubiquitinating enzyme (DUB), regulating key cellular pathways, including cell cycle, cellular differentiation, transcription and DNA damage response. Germline BAP1 mutations cause a novel cancer syndrome characterised by early onset of multiple atypical Spitz ...
Ami, Wang +4 more
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The BAP1 gene (BRCA1-associated protein 1) is a tumour suppressor gene that encodes a deubiquitinating enzyme (DUB), regulating key cellular pathways, including cell cycle, cellular differentiation, transcription and DNA damage response. Germline BAP1 mutations cause a novel cancer syndrome characterised by early onset of multiple atypical Spitz ...
Ami, Wang +4 more
openaire +2 more sources