Results 171 to 180 of about 2,356,155 (301)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Left Write Hook: proof of concept for a survivor-designed, and peer-led programme incorporating expressive writing and boxing to support mental health in adult survivors of child sexual abuse. [PDF]

Eur J Psychotraumatol
Veltman E, Smith A, Lyon D, Hitchcock C.
europepmc   +1 more source

Collaborative working mechanism and seismic effect analysis of assembled sandwich shear walls connected by double row reinforcing bars

Haiting Lu
openalex   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

HIV Seroprevalence, Incidence, and Viral Suppression Among Ugandan Males with Bar or Sex Worker Partners: A Population-Based Study

Xinyi Feng, M. Kate Grabowski, Fred Nalugoda, Godfrey Kigozi, Larry W. Chang, Andrea Wirtz, Caitlin Elizabeth Kennedy, Gertrude Nakigozi, Eshan Patel, Anthony Ndyanabo, Hadijja Nakawooya, Thomas C. Quinn, Ronald M. Galiwango, David Serwadda, Victor Ssempijja, Steven J. Reynolds, Aaron A.R. Tobian, Robert Ssekubugu   +17 more
openalex   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Aquaporin AtTIP5;1 negatively regulates nitric oxide-promoted lateral root development by affecting auxin transport and homeostasis of reactive oxygen species in roots of <i>Arabidopsis</i>. [PDF]

Plant Signal Behav
Zhu Q, Li P, Sun L, He S, Hao F.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Formulation and Evaluation of a "Matrisva"- Maternal Nutraceutical Chocolate Bar Enriched with DHA, Vitamin D₃, and Natural Folate Sources

Anuradha Shyam* Dr. Kavitha PN Suprajita Das*
openalex   +2 more sources

The Norma arm: star formation in a bar-driven shock front

Hillary Davis, J. Bland-Hawthorn, Thor Tepper-García, Oscar Agertz   +3 more
openalex   +1 more source