Results 101 to 110 of about 641,315 (246)

Mechanisms by which SNX-BAR subfamily controls the fate of SNXs’ cargo

Frontiers in Physiology
The SNX-BAR subfamily is a component of the sorting nexins (SNXs) superfamily. Distinct from other SNXs, which feature a PX domain for phosphoinositide binding, the SNX-BAR subfamily includes a BAR domain that induces membrane curvature.
Yaolin Long, Yang Li, Jin Xue, Wanqing Geng, Mingxia Ma, Xiaohui Wang, Li Wang   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Depletion or over-expression of Sh3px1 results in dramatic changes in cell morphology

Biology Open, 2015
The mammalian Sorting Nexin 9 (Snx9) family consists of three paralogs: Snx9, Snx18 and Snx33. Most of the published literature to date has centered on the role of Snx9 in clathrin-mediated endocytosis (CME). Snx9 contains an Sh3 domain at its N-terminus
Lawrence Hicks, Guojun Liu, Fiona P. Ukken, Sumin Lu, Kathryn E. Bollinger, Kate O'Connor-Giles, Graydon B. Gonsalvez   +6 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

SNX9: An Unconventional Bar Domain Protein? [PDF]

Biophysical Journal, 2021
Feng-Ching Tsai, Senthil Arumugam, John Manzi, Patricia M. Bassereau   +3 more
openaire   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Proposed fault diagnostics of a broken rotor bar induction motor fed from PWM inverter

Journal of Electrical Systems and Information Technology, 2016
This paper presents a fault diagnostics technique for a three-phase squirrel cage induction motor. The method is developed using a simplified model affected by bar resistance variation.
Faeka M.H. Khater, Mohamed I. Abu El-Sebah, Mohamed Osama, Khaled S. Sakkoury   +3 more
doaj   +1 more source

Tetraspanner-based nanodomains modulate BAR domain-induced membrane curvature. [PDF]

EMBO Rep, 2023
Haase D, Rasch C, Keller U, Tsytsyura Y, Glyvuk N, Elting A, Wittmar J, Janning A, Kahms M, Wedlich N, Schuberth C, Heuer A, Klingauf J, Wedlich-Söldner R.   +13 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source