Results 141 to 150 of about 3,184,320 (288)

Proposed schematic illustration of BIN1 N-BAR domain tubulating membrane.

, 2014
1) N-BAR domains bind on membrane; 2) Proteins oligomerize locally to create membrane buds; 3) N-BAR domains sense local curvature and diffuse onto the tubule to further elongate membrane tubule and stabilize the highly curved membrane; 4) Finally, the ...
Zheng Shi (586636), Tingting Wu (228837), Tobias Baumgart (183997)   +2 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Lockwood Letter. (Toledo, Ohio), approximately December 1992

, 2019
The Lockwood Letter is a newspaper published by the Toledo Women's Bar Association published in part to "promote and advance the position of and opportunities available to women attorneys" in the Toledo area.
Toledo Women's Bar Association
core  

An asymptotic model for the hydrodynamics of the thermal bar [PDF]

, 1995
An asymptotic solution is found for the temperature and circulation structure for an unsteady two-dimensional model of the thermal bar phenomenon. The non-rotating case considered here is relevant to laboratory models of the thermal bar.
Farrow, D.E.
core  

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

, 2008
International audienceThe BAR (Bin-Amphiphysin-Rvs) domain defines an emerging superfamily of proteins implicated in fundamental biological processes by sensing and inducing membrane curvature.
Ahmadian, M., Koessmeier, K., Eberth, A., Lundmark, Richard, Eberth, Alexander, Dvorsky, Radovan, Ahmadian, Mohammad Reza, Dvorsky, R., Koessmeier, Katja T, Lundmark, R., McMahon, H., Lundmark, Richard,, Gremer, L., Gremer, Lothar, McMahon, Harvey T   +14 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Signaling behind bars: a role for bar domains

, 2012
In this thesis we describe several novel components of growth factor receptor and RhoGTPase activation and signaling. We have demonstrated that the F-BAR protein PACSIN2 is an important regulator of Rac1 output and, as a consequence, cell spreading and migration.
openaire   +1 more source

Syriac lexicon Hasan Bar Bahlul. Volume 1

, 1886
The massive Syriac-Syriac/Arabic lexicon—actually more an encyclopedia than a mere lexicon—of Bar Bahlul (10th century) is one of two commonly cited Syriac dictionaries from the medieval period, the other being that of Bar Ali.
, Hassan bar Bahlul, active 10th century
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Thermodynamics and Free Energy Landscape of BAR-Domain Dimerization from Molecular Simulations. [PDF]

J Phys Chem B, 2021
Jhaveri A, Maisuria D, Varga M, Mohammadyani D, Johnson ME.   +4 more
europepmc   +1 more source