Results 211 to 220 of about 641,315 (246)

Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich, Alexis Ogdie, Alisa Stephens Shields, Peter A. Merkel, Shervin Assassi, Elana J. Bernstein, Andreea Bujor, Flavia V. Castelino, Lorinda Chung, Luke B. Evnin, Tracy M. Frech, Jessica K. Gordon, Melissa Griffith, Faye N. Hant, Monica L. Harding, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota J. Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Maureen D. Mayes, Zsuzsanna H. McMahan, Jerry Molitor, Duncan F. Moore, Julie Paik, Carrie Richardson, Brian Skaug, Ami A. Shah, Ankoor Shah, Virginia Steen, John M. VanBuren, Elizabeth R. Volkmann, Carleigh Zahn, Nora Sandorfi, for the CONQUER Investigators   +35 more
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Role of SH3 and BAR domains in fission yeast

, 2017
openaire   +1 more source

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Crystal Structure of the Endophilin-A1 BAR Domain

Journal of Molecular Biology, 2005
Endophilin has been implicated in the retrieval of membrane via endocytosis of clathrin-coated vesicles, which is crucial for the maintenance of neurotransmitter exocytosis during stimulation; both exocytosis and endocytosis are regulated by intracellular calcium levels.
Winfried Weissenhorn
exaly   +3 more sources

Structural characteristics of BAR domain superfamily to sculpt the membrane

Seminars in Cell and Developmental Biology, 2010
Membrane dynamics is an essential process for cell locomotion, cytokinesis, vesicular transport and organelle morphogenesis. Formation of tubes or buds from a nearly flat membrane is a widely spread feature of the membrane shape changes. The BAR (Bin/Amphiphysin/Rvs-homology) domain dimers exhibit long extended curved shapes and appear to be ...
Naoki Mochizuki
exaly   +3 more sources

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

Science, 2004
The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain.
Peter, Brian J, Kent, Helen M, Mills, Ian G, Vallis, Yvonne, Butler, P Jonathan G, Evans, Philip R, McMahon, Harvey T   +6 more
openaire   +3 more sources

BAR Domains Go on a Bender

Science, 2004
How do cells make vesicles, a process that requires the bending of membranes? In their Perspective, [Lee and Schekman][1] discuss new findings ([ Peter et al .][2]) that identify a domain called the BAR domain in proteins, such as amphiphysin and endophilin, that induces the curvature of membranes at different points during vesicle formation.
Lee, Marcus C.S., Schekman, Randy
openaire   +2 more sources

BAR domains and membrane curvature: bringing your curves to the BAR.

Biochemical Society Symposia, 2005
BAR (bin, amphiphysin and Rvs161/167) domains are a unique class of dimerization domains, whose dimerization interface is edged by a membrane-binding surface. In its dimeric form, the membrane-binding interface is concave, and this gives the ability to bind better to curved membranes, i.e. to sense membrane curvature.
Jennifer L, Gallop, Harvey T, McMahon
openaire   +2 more sources

I-BAR domains, IRSp53 and filopodium formation

Seminars in Cell & Developmental Biology, 2010
Filopodia and lamellipodia are dynamic actin-based structures that determine cell shape and migration. Filopodia are thought to sense the environment and direct processes such as axon guidance and neurite outgrowth. Cdc42 is a small GTP-binding protein and member of the RhoGTPase family.
Sohail, Ahmed, Wah Ing, Goh, Wenyu, Bu
openaire   +2 more sources

$$ \bar{\partial } $$ and $$ {\bar{\partial }_b} $$ Problems on Nonsmooth Domains

1999
In this survey article we want to describe our method for constructing barriers on weakly pseudoconvex domains with smooth boundaries and give some applications to nonsmooth pseudoconvex domains. We also consider annuli of a very general type which are difference sets of a large piecewise smooth pseudoconvex domain with a union of piecewise smooth ...
Joachim Michel, Mei-Chi Shaw
openaire   +1 more source