Results 31 to 40 of about 1,704,518 (313)
Lysosphingolipids in ceramide-deficient skin lipid models
Journal of Lipid ResearchCeramides are key components of the skin's permeability barrier. In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine ...
Georgios Paraskevopoulos +8 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Failure Assessment Methodologies for Pressure-Retaining Components under Severe Accident Loading
Science and Technology of Nuclear Installations, 2012 During postulated high-pressure core melt accident scenarios, temperature values of more than 800°C can be reached in the reactor coolant line and the surge line of a pressurised water reactor (PWR), before the bottom of the reactor pressure vessel ...
J. Arndt, H. Grebner, J. Sievers
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Gli agenti britannici al servizio dei «Granturisti» a Roma. Una lucrosa attività nel XVIII secolo
ArcHistoR Architettura Storia Restauro: Architecture History Restoration, 2015 Nel XVIII secolo la Roma degli artisti era intrinseca a quella di una cosmopolita popolazione di visitatori europei impegnati nel loro Grand Tour.
Janine Barrier
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
L’évaluation, outil de pilotage
Revue Internationale d’Éducation de Sèvres, 2000 For several years in Guinea, the Ministry of Education has been performing an ongoing evaluation programme for primary education as part of efforts to improve education quality. To date, this programme has focused, not on merely evaluating pupils’ levels,
Émilie Barrier
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ResnetAge: A Resnet-Based DNA Methylation Age Prediction Method
Bioengineering, 2023 Aging is a significant contributing factor to degenerative diseases such as cancer. The extent of DNA methylation in human cells indicates the aging process and screening for age-related methylation sites can be used to construct epigenetic clocks ...
Lijuan Shi +4 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Climate change and the Great Barrier Reef: a vulnerability assessment
, 2007 The Great Barrier Reef is renowned internationally for its ecological importance and the beauty of its seascapes and landscapes. These natural values also provide important ecosystem services, which underpin Australian $6.9 billion worth of economic ...
Skeat, A. +4 more
core +2 more sources
European Pharmaceutical Journal, 2017 The skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss ...
Vávrová K., Kováčik A., Opálka L.
doaj +1 more source