Results 61 to 70 of about 3,484,802 (301)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
La cire et le miel. Statut et fonction de la mémoire chez Huarte
Cahiers François VièteThis paper seeks to question the conception of memory that emerges from the Examen de ingenios para las ciencias (1575, 1594), by Juan Huarte de San Juan (1529-1588).
Thibault Barrier
doaj +1 more source
Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery
Pharmaceuticals, 2022 Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms.
Eleni Panoutsopoulou +3 more
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Thermal barrier pressure seal [PDF]
, 1980 An apparatus is described for providing thermal and pressure sealing in an elongated space of varying width between adjacent surface of two members. The apparatus is mounted for at least limited lateral movement between the members and may comprise: an ...
Bellavia, J., Jr., Kane, J. O.
core +1 more source
On barrier and modified barrier multigrid methods for 3d topology optimization [PDF]
, 2019 One of the challenges encountered in optimization of mechanical structures, in particular in what is known as topology optimization, is the size of the problems, which can easily involve millions of variables.
Brune, Alexander, Kocvara, Michal
core +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Metastable Evolutionary Dynamics: Crossing Fitness Barriers or Escaping via Neutral Paths?
, 1999 We analytically study the dynamics of evolving populations that exhibit metastability on the level of phenotype or fitness. In constant selective environments, such metastable behavior is caused by two qualitatively different mechanisms. One the one hand,
Crutchfield, James P. +1 more
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Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
SensorsMost multi-target movements are nonlinear in the process of movement. The common multi-target tracking filtering methods directly act on the multi-target tracking system of nonlinear targets, and the fusion effect is worse under the influence of ...
Liu Wang +4 more
doaj +1 more source