Results 61 to 70 of about 488,446 (257)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Diverse microbial interactions with the basement membrane barrier [PDF]

Trends in Microbiology, 2012
During primary contact with susceptible hosts, microorganisms face an array of barriers that thwart their invasion process. Passage through the basement membrane (BM), a 50-100-nm-thick crucial barrier underlying epithelia and endothelia, is a prerequisite for successful host invasion.
Steukers, Lennert, Glorieux, Sarah, Vandekerckhove, Annelies P., Favoreel, Herman W., Nauwynck, Hans J.   +4 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Silver-impregnated platelet-rich fibrin as a barrier membrane

Journal of Oral Research and Review, 2020
Introduction: Platelet-rich fibrin (PRF) was developed to eliminate xenofactors form of platelet-rich plasma to be used as a source of growth factor for tissue regeneration.
Dipali Chaudhari, Swapna Mahale, Arunkumar Mahale, Ayushya Warang, Lavanya Kalekar, Shraddha Shimpi   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Overcoming barriers to membrane protein structure determination [PDF]

Nature Biotechnology, 2011
After decades of slow progress, the pace of research on membrane protein structures is beginning to quicken thanks to various improvements in technology, including protein engineering and microfocus X-ray diffraction. Here we review these developments and, where possible, highlight generic new approaches to solving membrane protein structures based on ...
Bill, R, Henderson, P, Iwata, S, Kunji, E, Michel, H, Neutze, R, Newstead, S, Poolman, B, Tate, C, Vogel, H   +9 more
openaire   +4 more sources

Clinical trial landscape for guided bone regeneration: trend analysis and future perspectives

Frontiers in Dental Medicine
AimThis study aims to comprehensively analyse the developmental progress of bone graft materials and barrier membranes in the field of oral-maxillofacial bone regeneration, with a particular emphasis on emerging therapeutic approaches for bone ...
Yuqing Gui, Yuqing Gui, Xinyue Shen, Hongying Li, Junyi Lou, Junjie Cao, Jiang Yu, Zining Luo, Tianxiang Geng, Jiebin Xie   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Complementary Membranes Forming the Blood‐Brain Barrier [PDF]

IUBMB Life, 2002
AbstractBrain capillary endothelial cells form the blood‐brain barrier. They are connected by extensive tight junctions, and are polarized into luminal (blood‐facing) and abluminal (brain‐facing) plasma membrane domains. The polar distribution of transport proteins allows for active regulation of brain extracellular fluid.
Richard A, Hawkins, Darryl R, Peterson, Juan R, Viña   +2 more
openaire   +2 more sources