Results 71 to 80 of about 488,446 (257)
Research progress on guided tissue regeneration membrane
Kouqiang hemian waike zazhiPeriodontitis often leads to irreversible damage, and guided tissue regeneration (GTR) remains the primary therapeutic strategy for reconstructing lost hard tissue and periodontal attachment. However, current GTR membranes still face multiple limitations
YUAN Shuai, WANG Zuolin
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mBio, 2020 The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrobial peptides.
Junping Fan +4 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Prodrugs of Phosphonates and Phosphates: Crossing the Membrane Barrier [PDF]
, 2014 A substantial portion of metabolism involves transformation of phosphate esters, including pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and steroids, and phosphorylated proteins. Because the natural substrates bear one or more negative charges, drugs that target these enzymes generally must be charged as well, but ...
Andrew J, Wiemer, David F, Wiemer
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European Cells & MaterialsBackground: Guided bone regeneration (GBR) procedures require barrier membrane fixation to ensure membrane and graft stability. Recently, innovative resorbable fibrous gelatine membranes have been developed with a coating based on poly(2-oxazoline) (POx)
SEM Poos +6 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cell cytoskeletal changes effected by static compressive stress lead to changes in the contractile properties of tissue regenerative collagen membranes [PDF]
European Cells & Materials, 2013 Static compressive stress can influence the matrix, which subsequently affects cell behaviour and the cell’s ability to further transform the matrix.
K Gellynck +6 more
doaj
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Caspases disrupt mitochondrial membrane barrier function
FEBS Letters, 1998 Mitochondrial intermembrane proteins including cytochrome c are known to activate caspases. Accordingly, a disruption of the mitochondrial membrane barrier function with release of cytochrome into the cytosol has been shown to precede caspase activation in a number of different models of apoptosis.
Marzo, Isabel +7 more
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