Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier
Fluids and Barriers of the CNSBackground Nanocarriers targeting the blood-brain barrier (BBB) are promising drug delivery systems to enhance the penetration of therapeutic molecules into the brain.
Anikó Szecskó +9 more
doaj +1 more source
Fluids and Barriers of the CNS, 2019 This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year.
Adam Chodobski +6 more
doaj +1 more source
Barriers to Union Organizing [PDF]
, 1992 [Excerpt] The current environment presents dramatic challenges for the American labor movement. Structural change in the economy has meant job loss in traditionally unionized sectors such as heavy manufacturing, and job gains in the less unionized ...
Hurd, Richard W
core +1 more source
Barriers to the successful exploitation of ERP systems in Chinese state-owned enterprises
, 2010 Adopting a systems perspective, the research presented in this paper aims at identifying, assessing and discussing potential cultural, organisational and system barriers to the successful exploitation of Enterprise Resource Planning (ERP) systems in the ...
Nunes, J.M.B., Peng, G.C.
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Policy Barriers to School Improvement: What's Real and What's Imagined? [PDF]
, 2014 Some of the most promising reforms are happening where school leaders are thinking differently about how to get the strongest student outcomes from the limited resources available.
Jane S. Lee, Lawrence J. Miller
core
Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative. [PDF]
, 2018 Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to ...
Benjamin, Daniel K +12 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Barriers and Bridges: An Action Plan for Overcoming Obstacles and Unlocking Opportunities for African American Men in Pittsburgh [PDF]
, 2015 Among the region's residents, Pittsburgh's African American men have historically and disproportionately faced unprecedented barriers to economic opportunities. This study, supported by The Heinz Endowments, focuses on structural barriers that contribute
Christopher Lowenstein +3 more
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