Results 51 to 60 of about 32,167,916 (377)

Repression of GW/P body components and the RNAi microprocessor impacts primary ciliogenesis in human astrocytes

BMC Cell Biology, 2011
Background In most cells, the centriolar component of the centrosome can function as a basal body supporting the formation of a primary cilium, a non-motile sensory organelle that monitors information from the extracellular matrix and relays stimuli into
Rattner Jerome B, Fritzler Marvin J, Moser Joanna J   +2 more
doaj   +1 more source

The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly.

PLoS Biology, 2022
In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface, and docking to the plasma membrane.
Pierrick Le Borgne, Logan Greibill, Marine Hélène Laporte, Michel Lemullois, Khaled Bouhouche, Mebarek Temagoult, Olivier Rosnet, Maeva Le Guennec, Laurent Lignières, Guillaume Chevreux, France Koll, Virginie Hamel, Paul Guichard, Anne-Marie Tassin   +13 more
doaj   +1 more source

The management of type 2 diabetes with fixed‐ratio combination insulin degludec/liraglutide (IDegLira) versus basal‐bolus therapy (insulin glargine U100 plus insulin aspart): a short‐term cost‐effectiveness analysis in the UK setting [PDF]

, 2018
Aim: To evaluate the cost‐effectiveness of IDegLira versus basal‐bolus therapy (BBT) with insulin glargine U100 plus up to 4 times daily insulin aspart for the management of type 2 diabetes in the UK.
ADVANCE Collaborative Group, American Diabetes Association Consensus Panel, Anderson, Bagust, Bagust, Billings, Blak, Boye, Chubb, Control Group, Currie, Donnelly, Duckworth, Evans, Forst, Gaede, Gaede, Giugliano, Grandy, Hammer, Holman, Hunt, Hunt, Hunt, Inzucchi, Ismail-Beigi, Johnston, Lee, Matza, McCabe, Meneghini, Mezquita-Raya, National Institute for Health and Care Excellence (NICE), Nauck, Parekh, Peyrot, Peyrot, Ridderstråle, Russell-Jones, Shi, Stettler, The Forum for Injection Technique (FIT), TREND-UK, UK Prospective Diabetes Study (UKPDS) Group, UK Prospective Diabetes Study (UKPDS) Group, Walz, Wang, Wild   +47 more
core   +1 more source

Replication of basal bodies and centrioles

Current Opinion in Cell Biology, 1992
During the past year, studies on the centrioles and basal bodies of animal and algal cells, and the spindle pole bodies of yeast and other fungi, have added significantly to our knowledge of how these cell organelles form and how they function in initiating microtubule assembly throughout the cell cycle.
Johnson, Karl A., Rosenbaum, Joel L.
openaire   +3 more sources

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery

Nature Genetics, 2016
Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular signaling. Ciliopathies are a spectrum of human diseases resulting from defects in cilia structure or function.
Michinori Toriyama, Chanjae Lee, S. P. Taylor, Ivan Duran, D. Cohn, A. Bruel, Jacqueline M. Tabler, K. Drew, M. Kelly, Sukyoung Kim, Tae Joo Park, Tae Joo Park, Daniella Braun, Daniella Braun, G. Pierquin, A. Biver, K. Wagner, A. Malfroot, I. Panigrahi, B. Franco, H. A. Al-lami, Yvonne Yeung, Yeon Ja Choi, Y. Duffourd, L. Faivre, J. Rivière, Jiang Chen, Karen J. Liu, E. Marcotte, F. Hildebrandt, F. Hildebrandt, C. Thauvin-Robinet, D. Krakow, P. Jackson, J. Wallingford   +34 more
semanticscholar   +1 more source

Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs

Cells, 2018
Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole.
Umama Shahid, Priyanka Singh
doaj   +1 more source

BASAL BODIES, BUT NOT CENTRIOLES, IN NAEGLERIA [PDF]

The Journal of Cell Biology, 1971
Amebae of Naegleria gruberi transform into flagellates whose basal bodies have the typical centriole-like structure. The amebae appear to lack any homologous structure, even during mitosis. Basal bodies are constructed during transformation and, in cells transforming synchronously at 25°C, they are first seen about 10 min before flagella are seen.
Chandler Fulton, Allan D. Dingle
openaire   +3 more sources

Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

eLife, 2017
The primary cilium is nucleated by the mother centriole-derived basal body (BB) via as yet poorly characterized mechanisms. BBs have been reported to degenerate following ciliogenesis in the C.
I. Nechipurenko, C. Berciu, P. Sengupta, D. Nicastro   +3 more
semanticscholar   +1 more source

Basal body temperature as a biomarker of healthy aging. [PDF]

Age (Dordr), 2016
Simonsick EM, Meier HCS, Shaffer NC, Studenski SA, Ferrucci L.   +4 more
europepmc   +2 more sources

Regulation of cilia abundance in multiciliated cells

eLife, 2019
Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification.
Rashmi Nanjundappa, Dong Kong, Kyuhwan Shim, Tim Stearns, Steven L Brody, Jadranka Loncarek, Moe R Mahjoub   +6 more
doaj   +1 more source