Results 111 to 120 of about 526,321 (280)

Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice

Frontiers in Molecular Neuroscience
IntroductionRisperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and induce spatially discrete ...
Magdalena Ziemiańska, Mateusz Zięba, Anna Radlicka-Borysewska, Łukasz Szumiec, Sławomir Gołda, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Jan Rodriguez Parkitna   +8 more
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Subregion-specific input organization of prefrontal-projecting basal forebrain cholinergic neurons and weakened striatal–NBM inhibitory transmission in 5xFAD mice

Neurobiology of Disease
Basal forebrain cholinergic neurons regulate cortical activity and cognition and are vulnerable in Alzheimer’s disease (AD). However, the upstream circuits controlling projection-defined basal forebrain cholinergic populations remain incompletely ...
Yufei Huang, Xueyi Xie, Michael Fernaine, Ziyi Li, Xuehua Wang, Jun Wang   +5 more
doaj   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Atrophy of the cholinergic basal forebrain can detect presynaptic cholinergic loss in Parkinson's Disease

, 2023
Objectives: Structural imaging of the cholinergic basal forebrain may provide a biomarker for cholinergic system integrity that can be used in motor and non-motor outcome studies in Parkinson's disease.
Prabesh Kanel (13986030), Nicola J Ray (17443657), Nicolaas I Bohnen (24029235)   +2 more
core  

Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery

Epilepsia, EarlyView.
Abstract Objective Resective surgery achieves seizure freedom in approximately 60%–80% of patients with drug‐resistant temporal lobe epilepsy (TLE), yet the extent to which seizure cessation permits recovery of disrupted functional brain networks remains unclear.
Addison C. Cavender, Derek J. Doss, Ghassan S. Makhoul, Bruno Hidalgo Monroy Lerma, Anas Reda, C. Price Withers, Emily Liao, Kate Wang, Hernán F. J. González, Sarah E. Goodale, Graham W. Johnson, Laurie E. Cutting, Sarah K. Bick, Catie Chang, Victoria L. Morgan, Dario J. Englot   +15 more
wiley   +1 more source

Remote memory after basal forebrain damage

, 1998
Babinsky R, Markowitsch HJ, Engel H. Remote memory after basal forebrain damage. NEUROPSYCHIATRY NEUROPSYCHOLOGY AND BEHAVIORAL NEUROLOGY.
Markowitsch, Hans J., Babinsky, R, Engel, H   +2 more
core  

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Epilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher, Mathias Woidy, Franziska Plein, Tatjana Bierhals, Leonie von Elsner, Theresia Herget, Maja Hempel, Fanny Kortüm, Lev Grinstein, Julia V. Cramer, Jessika Johannsen, Jonas Denecke   +11 more
wiley   +1 more source

The basal ganglia and the epilepsies

Epilepsia Open, EarlyView.
Abstract The basal ganglia are an evolutionarily conserved neural circuit best known for the selection and sequencing of voluntary movement. Increasing evidence, however, indicates that these structures also play an important role in regulating pathological brain states, including seizures.
Willian Lazarini‐Lopes, Logan Perry, Patrick A. Forcelli   +2 more
wiley   +1 more source