Single-nucleus transcriptomics uncovers region-specific molecular features underlying selective aging vulnerability of cholinergic neurons [PDF]
iScienceSummary: Cholinergic neurons exhibit functional and molecular heterogeneity across the basal forebrain (BF), midbrain (MB), and brainstem (BS), while the aging-associated transcriptional features remain poorly characterized.
Qianqian Li +5 more
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Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons [PDF]
Frontiers in Neural Circuits, 2023 Acetylcholine and GABA are often co-released, including from VIP-expressing neurons of the cortex, cortically-projecting neurons of the globus pallidus externus and basal forebrain, and hippocampal-projecting neurons of the medial septum.
Adam J. Granger +4 more
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Inhibition of midbrain cholinergic neurons impairs decision-making strategies during reversal learning [PDF]
Frontiers in Molecular NeuroscienceIntroductionThe pedunculopontine nucleus (PPN) plays a role in coordinating complex behaviors and adapting to changing environmental conditions. The specific role of cholinergic neurons in PPN function is not well understood, but their ascending ...
Yuwoong Kim +3 more
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Functionally linked amygdala and prefrontal cortical regions are innervated by both single and double projecting cholinergic neurons [PDF]
Frontiers in Cellular NeuroscienceCholinergic cells have been proposed to innervate simultaneously those cortical areas that are mutually interconnected with each other. To test this hypothesis, we investigated the cholinergic innervation of functionally linked amygdala and prefrontal ...
Bence Barabás +8 more
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Physiological properties of cholinergic and non-cholinergic magnocellular neurons in acute slices from adult mouse nucleus basalis. [PDF]
PLoS ONE, 2010 BackgroundThe basal forebrain is a series of nuclei that provides cholinergic input to much of the forebrain. The most posterior of these nuclei, nucleus basalis, provides cholinergic drive to neocortex and is involved in arousal and attention.
Tristan Hedrick, Jack Waters
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Characterization of Channelrhodopsin and Archaerhodopsin in Cholinergic Neurons of Cre-Lox Transgenic Mice. [PDF]
PLoS ONE, 2016 The study of cholinergic signaling in the mammalian CNS has been greatly facilitated by the advent of mouse lines that permit the expression of reporter proteins, such as opsins, in cholinergic neurons. However, the expression of opsins could potentially
Tristan Hedrick +7 more
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Frontiers in Cellular Neuroscience, 2022 Modulation of neural circuits is essential for flexible sensory perception and decision-making in a changing environment. Cholinergic and GABAergic projections to the olfactory system from the horizontal limb of the diagonal band of Broca (HDB) in the ...
Ping Zhou +4 more
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Basal Forebrain Cholinergic Activity Modulates Isoflurane and Propofol Anesthesia
Frontiers in Neuroscience, 2020 Cholinergic neurons in the basal forebrain (BF) have long been considered to be the key neurons in the regulation of cortical and behavioral arousal, and cholinergic activation in the downstream region of the BF can arouse anesthetized rats.
Tian-Yuan Luo +13 more
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Nature Communications, 2023 Nucleus- and cell-specific interrogation of individual basal forebrain (BF) cholinergic circuits is crucial for refining targets to treat comorbid chronic pain-like and depression-like behaviour.
Ya-Wei Ji +12 more
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Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus. [PDF]
PLoS ONE, 2016 The cholinoceptive system in the hypothalamus, in particular in the arcuate nucleus (ARC), plays a role in regulating food intake. Neurons in the ARC contain multiple neuropeptides, amines, and neurotransmitters.
Jae Hoon Jeong +3 more
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