Results 11 to 20 of about 85,202 (263)

Cholinergic Neuronal Deficits in CADASIL [PDF]

Stroke, 2007
Background and Purpose— Previous evidence from MRI and acetylcholinesterase histochemistry suggests cholinergic fibers are affected in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Methods—
Jessica S, Keverne, Wee Chuang R, Low, Iryna, Ziabreva, Jenny A, Court, Arthur E, Oakley, Raj N, Kalaria   +5 more
openaire   +2 more sources

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

Frontiers in Pharmacology, 2022
Airway cholinergic nerves play a key role in airway physiology and disease. In asthma and other diseases of the respiratory tract, airway cholinergic neurons undergo plasticity and contribute to airway hyperresponsiveness and mucus secretion.
P. A. Goldsteen, P. A. Goldsteen, A. M. Sabogal Guaqueta, P. P. M. F. A. Mulder, I. S. T. Bos, I. S. T. Bos, M. Eggens, L. Van der Koog, L. Van der Koog, J. T. Soeiro, A. J. Halayko, K. Mathwig, L. E. M. Kistemaker, L. E. M. Kistemaker, L. E. M. Kistemaker, E. M. J. Verpoorte, A. M. Dolga, A. M. Dolga, R. Gosens, R. Gosens   +19 more
doaj   +1 more source

Cholinergic neurons in the dorsomedial hypothalamus regulate food intake

Molecular Metabolism, 2017
Objective: Central cholinergic neural circuits play a role in the regulation of feeding behavior. The dorsomedial hypothalamus (DMH) is considered the appetite-stimulating center and contains cholinergic neurons.
Jae Hoon Jeong, Dong Kun Lee, Young-Hwan Jo   +2 more
doaj   +1 more source

Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits

Translational Psychiatry, 2023
Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-spectrum disorder (ASD), but the pathogenic mechanisms are not well understood.
Maximiliano Rapanelli, Wei Wang, Edward Hurley, Maria Laura Feltri, Christopher Pittenger, Luciana Romina Frick, Zhen Yan   +6 more
doaj   +1 more source

17β-estradiol does not have a direct effect on the function of striatal cholinergic interneurons in adult mice in vitro

Frontiers in Endocrinology, 2023
The striatum is an essential component of the basal ganglia that is involved in motor control, action selection and motor learning. The pathophysiological changes of the striatum are present in several neurological and psychiatric disorder including ...
Erzsébet Kövesdi, Erzsébet Kövesdi, Ildikó Udvarácz, Ildikó Udvarácz, Angéla Kecskés, Angéla Kecskés, Szilárd Szőcs, Szilárd Szőcs, Szidónia Farkas, Szidónia Farkas, Péter Faludi, Péter Faludi, Tibor Z. Jánosi, Tibor Z. Jánosi, István M. Ábrahám, István M. Ábrahám, Gergely Kovács, Gergely Kovács   +17 more
doaj   +1 more source

New Insights Into Cholinergic Neuron Diversity [PDF]

Frontiers in Molecular Neuroscience, 2019
Cholinergic neurons comprise a small population of cells in the striatum but have fundamental roles in fine tuning brain function, and in the etiology of neurological and psychiatric disorders such as Parkinson's disease (PD) or schizophrenia. The process of developmental cell specification underlying neuronal identity and function is an area of great ...
Ahmed, Noorya Yasmin, Knowles, Rhys, Dehorter, Nathalie   +2 more
openaire   +5 more sources

Whole-brain mapping of monosynaptic inputs to midbrain cholinergic neurons

Scientific Reports, 2021
The cholinergic midbrain is involved in a wide range of motor and cognitive processes. Cholinergic neurons of the pedunculopontine (PPN) and laterodorsal tegmental nucleus (LDT) send long-ranging axonal projections that target sensorimotor and limbic ...
Icnelia Huerta-Ocampo, Daniel Dautan, Nadine K. Gut, Bakhtawer Khan, Juan Mena-Segovia   +4 more
doaj   +1 more source

A selective degeneration of cholinergic neurons mediated by NRADD in an Alzheimer's disease mouse model

Cell Insight, 2022
Cholinergic neurons in the basal forebrain constitute a major source of cholinergic inputs to the forebrain, modulate diverse functions including sensory processing, memory and attention, and are vulnerable to Alzheimer's disease (AD).
Lanfang Li, Bing Zhang, Xiaomei Tang, Quntao Yu, Aodi He, Youming Lu, Xinyan Li   +6 more
doaj   +1 more source

Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons

Molecular Neurodegeneration, 2010
Background Septal cholinergic neurons account for most of the cholinergic innervations of the hippocampus, playing a key role in the regulation of hippocampal synaptic activity.
Inestrosa Nibaldo C, Pissani Claudia A, Mauna Jocelyn C, Lazo Oscar M, Bronfman Francisca C   +4 more
doaj   +1 more source

Overnight fasting regulates inhibitory tone to cholinergic neurons of the dorsomedial nucleus of the hypothalamus. [PDF]

PLoS ONE, 2013
The dorsomedial nucleus of the hypothalamus (DMH) contributes to the regulation of overall energy homeostasis by modulating energy intake as well as energy expenditure.
Florian Groessl, Jae Hoon Jeong, David A Talmage, Lorna W Role, Young-Hwan Jo   +4 more
doaj   +1 more source