Results 21 to 30 of about 85,202 (263)

The Input-Output Relationship of the Cholinergic Basal Forebrain

Cell Reports, 2017
Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and attention. They collectively innervate the entire cerebral cortex, differentially controlling acetylcholine efflux across different cortical areas and timescales ...
Matthew R. Gielow, Laszlo Zaborszky
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Postsynaptic histamine H3 receptors in ventral basal forebrain cholinergic neurons modulate contextual fear memory

Cell Reports, 2023
Summary: Overly strong fear memories can cause pathological conditions. Histamine H3 receptor (H3R) has been viewed as an optimal drug target for CNS disorders, but its role in fear memory remains elusive.
Yanrong Zheng, Lishi Fan, Zhuowen Fang, Zonghan Liu, Jiahui Chen, Xiangnan Zhang, Yi Wang, Yan Zhang, Lei Jiang, Zhong Chen, Weiwei Hu   +10 more
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The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice

Frontiers in Cellular Neuroscience, 2015
The pedunculopontine nucleus is known as a cholinergic nucleus of the reticular activating system, participating in regulation of sleep and wakefulness. Besides cholinergic neurons, it consists of GABAergic and glutamatergic neurons as well.
Csilla eBordas, Adrienn eKovacs, Balazs ePal   +2 more
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Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

Molecular Metabolism, 2015
Objective: Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis.
Jae Hoon Jeong, Dong Kun Lee, Clemence Blouet, Henry H. Ruiz, Christoph Buettner, Streamson Chua, Jr., Gary J. Schwartz, Young-Hwan Jo   +7 more
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66108 Central Cholinergic Synapse Formation in Optimized Primary Septal “Hippocampal Co” cultures

Journal of Clinical and Translational Science, 2021
IMPACT: Optimization of primary septal-hippocampal co-cultures facilitates studying central cholinergic synapse formation and dysfunction OBJECTIVES/GOALS: Septal cholinergic innervation to the hippocampus is critical for normal learning and memory and ...
Sarra Djemil, Claire R. Ressel, Amanda K. Schneeweisi, S. Abdel-Ghani, Daniel T.S. Pak   +4 more
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Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms

Frontiers in Neural Circuits, 2015
Cholinergic neurons of the pedunculopontine nucleus (PPN) are most active during the waking state. Their activation is deemed to cause a switch in the global brain activity from sleep to wakefulness, while their sustained discharge may contribute to ...
Anne ePetzold, Miguel eValencia, Miguel eValencia, Balazs ePal, Juan eMena-Segovia, Juan eMena-Segovia   +5 more
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Striatal CDK5 Regulates Cholinergic Neuron Activation and Dyskinesia-like Behaviors through BK Channels

Research, 2023
Disturbance of the cholinergic system plays a crucial role in the pathological progression of neurological diseases that cause dyskinesia-like behaviors. However, the molecular mechanisms underlying this disturbance remain elusive.
Chu Tong, Peng-Xiang Min, Qian Zhang, Ru-Xin Gu, Yao-Hai Wen, Yi Shi, Yu-Huan Bao, Xiang Chen, Yi-Xuan Zhang, Xing-Feng Mao, Hao-Yang Yuan, Xiu-Xiu Liu, Takuya Sasaki, Li Zhang, Feng Han, Ying-Mei Lu   +15 more
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The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

eLife, 2021
Human reproduction is controlled by ~2000 hypothalamic gonadotropin-releasing hormone (GnRH) neurons. Here, we report the discovery and characterization of additional ~150,000–200,000 GnRH-synthesizing cells in the human basal ganglia and basal forebrain.
Katalin Skrapits, Miklós Sárvári, Imre Farkas, Balázs Göcz, Szabolcs Takács, Éva Rumpler, Viktória Váczi, Csaba Vastagh, Gergely Rácz, András Matolcsy, Norbert Solymosi, Szilárd Póliska, Blanka Tóth, Ferenc Erdélyi, Gábor Szabó, Michael D Culler, Cecile Allet, Ludovica Cotellessa, Vincent Prévot, Paolo Giacobini, Erik Hrabovszky   +20 more
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Subregion-specific input organization of prefrontal-projecting basal forebrain cholinergic neurons and weakened striatal–NBM inhibitory transmission in 5xFAD mice

Neurobiology of Disease
Basal forebrain cholinergic neurons regulate cortical activity and cognition and are vulnerable in Alzheimer’s disease (AD). However, the upstream circuits controlling projection-defined basal forebrain cholinergic populations remain incompletely ...
Yufei Huang, Xueyi Xie, Michael Fernaine, Ziyi Li, Xuehua Wang, Jun Wang   +5 more
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Choline acetyltransferase-containing neurons in the human parietal neocortex

European Journal of Histochemistry, 2009
A number of immunocytochemical studies have indicated the presence of cholinergic neurons in the cerebral cortex of various species of mammals. Whether such cholinergic neurons in the human cerebral cortex are exclusively of subcortical origin is still ...
V Benagiano, D Virgintino, P Flace, F Girolamo, M Errede, L Roncali   +5 more
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