Results 201 to 210 of about 526,321 (280)

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı, Burak Kahveci, Çağla Kiser, Nurhan Özlü, Gökhan Karakülah, Şermin Genç, Sinan Güven   +6 more
wiley   +1 more source

Association of dopamine depletion and cholinergic basal forebrain atrophy with brain metabolism and cognition in Parkinson's disease. [PDF]

J Parkinsons Dis
Hyun Lee J, Park M, Ahn SJ, Lee JH, Lee JH, Ryu YH, Yoo HS, Lyoo CH.   +7 more
europepmc   +1 more source

Plag1 Regulates Sensorimotor Modulation in Zebrafish

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
PLAG1 regulates early neurobehavioural development in zebrafish. Reducing plag1 alters craniofacial patterning, increases thigmotaxis and changes responses to light and acoustic stimuli, while gross brain structure and motor neuron development remain largely intact.
Jemma G. Gasperoni, Jarrad N. Fuller, April L. Lewis, Travis K. Johnson, Bert De Groef, Sebastian Dworkin   +5 more
wiley   +1 more source

Respiration-coordinated attentional switch from feedforward to top-down informational flow directed by the basal forebrain: layer-specific blanket inhibition of pyramidal cells by neurogliaform cells in the piriform cortex. [PDF]

Front Neural Circuits
Mori K, Sakano H.
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Inhibition of Abnormal Elevated α‐Synuclein Ameliorates Dopaminergic Neuron Degeneration in Parkinson's Disease Mouse Model

Aging Cell, Volume 25, Issue 10, October 2026.
α‐Syn‐HDOs protect dopaminergic neurons by enhancing BDNF–TrkB signaling through the inhibition of abnormally elevated α‐Syn. These findings position α‐Syn‐HDOs as promising therapeutic candidates for PD and suggest that BDNF may serve as a potential diagnostic biomarker or indicator of treatment efficacy.
Xuenan Wang, Yiru Ding, Lujuan He, Xizhi Kang, Xiwen Geng, Fumika Sakaue, Takanori Yokota, Liang‐wen Zhang, Wei Yao, Ji‐chun Zhang   +9 more
wiley   +1 more source

A Simple Three-Dimensional Compartmentalized Co-Culture Model for Basal Forebrain and Hippocampal Neurons. [PDF]

Biology (Basel)
Luo X, Li J, Deng Z, Xu Y, Li X, Ren M, Li X.   +6 more
europepmc   +1 more source

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama, Guanxiao Qi, Gabriele Radnikow, Danqing Yang, Dirk Feldmeyer   +4 more
wiley   +1 more source