Results 71 to 80 of about 45,649 (267)

Activation of Basal Forebrain Astrocytes Induces Wakefulness without Compensatory Changes in Sleep Drive [PDF]

, 2023
Ashley M. Ingiosi, Christopher R. Hayworth, Marcos G. Frank   +2 more
openalex   +1 more source

Cholinergic basal forebrain system degeneration underlies postural instability/gait difficulty and attention impairment in Parkinson's disease [PDF]

, 2023
Chenqing Wu, Haoting Wu, Cheng Zhou, Xiaojun Guan, Tao Guo, Zhengye Cao, Jingjing Wu, Xiaocao Liu, Jingwen Chen, Jiaqi Wen, Jianmei Qin, Sijia Tan, Xiaojie Duanmu, Weijin Yuan, Qianshi Zheng, Baorong Zhang, Peiyu Huang, Xiaojun Xu, Minming Zhang   +18 more
openalex   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Comparative Neuromechanical Wing‐Actuation Architectures of Flapping Flight in Insects, Hummingbirds, and Robots

Advanced Intelligent Systems, EarlyView.
Natural fliers achieve remarkable aerial performance through diverse wing neuromechanical systems integrating actuation, sensing, and control. This study synthesizes neuromechanical architectures in insects and hummingbirds, identifying two key functional types‐Dual Neural‐Mechanical Oscillator and Neurally‐modulated Mechanical Oscillator‐ and ...
Suyash Agrawal, Jean‐Michel Mongeau, Bret W. Tobalske, Christopher Rahn, Bo Cheng   +4 more
wiley   +1 more source

Effects of Neural Stem Cells combine with Nerve Growth Factor Nanoparticles Transplantation in Alzheimer's Disease Transgenic Mice

康复学报, 2021
Objective:To observe the effect of nerve growth factor(NGF)nanoparticles on the survival, migration and differentiation of transplanted neural stem cells(NSC)in the brain of APP/PS1 transgenic mice, and the effect of NSC combined with NGF nanoparticles ...
Qing ZHU, Shuai SHAO, Nan HU, Yan CHEN
doaj  

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

Animal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo, Ru Ye, Lu Guan, Wei He, Shuang Qiu, Xiaomei Shao, Junfan Fang, Jianqiao Fang, Junying Du   +8 more
wiley   +1 more source

Reward contingency gates selective cholinergic suppression of amygdala neurons

eLife
Basal forebrain cholinergic neurons modulate how organisms process and respond to environmental stimuli through impacts on arousal, attention, and memory.
Eyal Y Kimchi, Anthony Burgos-Robles, Gillian A Matthews, Tatenda Chakoma, Makenzie Patarino, Javier C Weddington, Cody Siciliano, Wannan Yang, Shaun Foutch, Renee Simons, Ming-fai Fong, Miao Jing, Yulong Li, Daniel B Polley, Kay M Tye   +14 more
doaj   +1 more source

Behavior Decoding Delineates Seizure Microfeatures and Associated Sudden Death Risks in Mouse Models of Epilepsy

Annals of Neurology, EarlyView.
Objective Behavior and motor manifestations are distinctive yet often overlooked features of epileptic seizures. Seizures can result in transient disruptions in motor control, often organized into specific behavioral sequences that can inform seizure types, onset zones, and outcomes.
Yuyan Shen, Jaden Thomas, Xianhui Chen, Jaden Zelidon, Mariam Najeeb, Abigayle Hahn, Ping Zhang, Aaron Sathyanesan, Bin Gu   +8 more
wiley   +1 more source

Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer’s Disease [PDF]

, 2020
Melissa J. Alldred, Sai C. Penikalapati, Sang H. Lee, Adriana Heguy, Panos Roussos, Stephen D. Ginsberg   +5 more
openalex   +1 more source