Regionalization of the Developing Hypothalamus: The Prosomeric and Tripartite Models [PDF]
CellsThe hypothalamus is a conserved structure in the brain of vertebrates that plays key roles in the organism’s homeostasis through different functions, including regulation of temperature, sleep, energy balance and reproduction.
Marika Kapsimali
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Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice [PDF]
Frontiers in Molecular NeuroscienceIntroductionRisperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and induce spatially discrete ...
Magdalena Ziemiańska +8 more
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Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors [PDF]
Nature CommunicationsThe dorsal raphe nucleus (DRN) shapes behaviors including mood and motivation. The DRN contains molecularly distinct and topographically organized neurons that target specific forebrain regions.
Aytac Kadir Mutlu +9 more
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Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
Frontiers in Cell and Developmental Biology, 2021 Function of the mature central nervous system (CNS) requires a substantial proportion of the body’s energy consumption. During development, the CNS anlage must maintain its structure and perform stage-specific functions as it proceeds through discrete ...
Ryann M. Fame, Maria K. Lehtinen
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Neuromorphological Atlas of Human Prenatal Brain Development: White Paper
Life, 2023 Recent morphological data on human brain development are quite fragmentary. However, they are highly requested for a number of medical practices, educational programs, and fundamental research in the fields of embryology, cytology and histology ...
Alexandra Proshchina +9 more
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Biomedicines, 2021 Phosphorylation of H2AX is a response to DNA damage, but γH2AX also associates with mitosis and/or apoptosis. We examined the effects of X-rays on DNA integrity to shed more light on the significance of H2AX phosphorylation and its relationship with ...
Nadia Gionchiglia +3 more
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Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures [PDF]
Open Biology, 2013 Several studies have successfully produced a variety of neural cell types from human embryonic stem cells (hESCs), but there has been limited systematic analysis of how different regional identities are established using well-defined differentiation ...
Giuseppe Lupo +8 more
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Medičnì Perspektivi, 2023 The relevance of the study is related to the high frequency of blast-induced brain injury in both military and civilian populations, which is caused by the use of various types of explosives in military conflicts, including in Ukraine today.
Yu.V. Kozlova
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Teleost Fish and Organoids: Alternative Windows Into the Development of Healthy and Diseased Brains
Frontiers in Molecular Neuroscience, 2022 The variety in the display of animals’ cognition, emotions, and behaviors, typical of humans, has its roots within the anterior-most part of the brain: the forebrain, giving rise to the neocortex in mammals.
Giulia Fasano +4 more
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Frontiers in Cell and Developmental Biology, 2023 The specification of the forebrain relies on the precise regulation of WNT/ß-catenin signalling to support neuronal progenitor cell expansion, patterning, and morphogenesis.
Shuang Geng +9 more
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