Results 11 to 20 of about 136,208 (293)
Biases in facial and vocal emotion recognition in chronic schizophrenia
There has been extensive research on impaired emotion recognition in schizophrenia in the facial and vocal modalities. The literature points to biases toward non-relevant emotions for emotional faces but few studies have examined biases in emotional ...
Thibaut eDondaine+11 more
doaj +1 more source
Rodent models of impulsive–compulsive behaviors in Parkinson's disease: How far have we reached?
There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive–compulsive behaviors (ICBs).
M. Angela Cenci+3 more
doaj +1 more source
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow ...
Irene Sebastianutto+2 more
doaj +1 more source
How ‘Basal' Are the Basal Ganglia? [PDF]
years ago [Erwin et al., 2011], did not merely have a substantial rostral brain, but specifically a telencephalon, an elaborate set of forebrain structures hitherto recognized only in vertebrates. The set of structures that Strausfeld and Hirth [2013a] identify as the arthropod homolog of the basal ganglia is the central complex, a group of median ...
openaire +3 more sources
Neurotransmitters in the Basal Ganglia [PDF]
ABSTRACTThe literature is reviewed on the afferents and efferents of the caudate/putamen, globus pallidus and substantia nigra, and on the neurotransmitters occurring in the various tracts. Emphasis is placed upon the diverse roles played by GABA and glutamate as transmitters in motor pathways and upon the probability that the substantia nigra pars ...
Edith G. McGeer+2 more
openaire +3 more sources
Mice with striatal 6-hydroxydopamine (6-OHDA) lesions are widely used as a model to study the effects of neurorestorative, symptomatic, or antidyskinetic treatments for Parkinson's disease (PD).
Francesco Bez+2 more
doaj +1 more source
Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of ...
Irene Sebastianutto+3 more
doaj +1 more source
Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD).
Christine Konradi+7 more
doaj +1 more source
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo+5 more
doaj +1 more source
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane+2 more
doaj +1 more source