Results 261 to 270 of about 27,260,641 (372)

Effect of subthalamic nucleus lesion on mitochondrial enzyme activity in rat basal ganglia

, 1995
Fabio Blandini, J. Timothy Greenamyre
openalex   +1 more source

Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D4R) Antagonist in vitro Tool compounds

ChemMedChem, EarlyView.
The work presents details of the efforts to design and characterize novel D4 inhibitors. A new 4,4‐difluoropiperidine ether series that confers improved potency and selectivity for D4 versus the other dopamine receptor subtypes is identified. Extensive structure‐activity relationship around this privileged group identifies the key structural changes to
Saeedeh Saeedi, Sumaiya Nahid, Anish K. Vadukoot, Corey R. Hopkins   +3 more
wiley   +1 more source

Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

, 1995
Fabio Blandini, Richard H. Porter, J. Timothy Greenamyre   +2 more
openalex   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Correction: Electrophysiological signatures of anxiety in Parkinson’s disease

Translational Psychiatry
Sahar Yassine, Sourour Almarouk, Ute Gschwandtner, Manon Auffret, Peter Fuhr, Marc Verin, Mahmoud Hassan   +6 more
doaj   +1 more source

Systemic Primary Carnitine Deficiency Presenting With Substantia Nigra and Basal Ganglia Injury: A Case Report. [PDF]

JIMD Rep
Saito T, Soma K, Kashisaka M, Iketani K, Matsumoto M, Ueda T, Nishiyama M, Maruyama A, Nakai R, Sakihama H, Kurosawa H, Morisada N, Kobayashi H, Ozaki K.   +13 more
europepmc   +1 more source

The direct basal ganglia pathway is hyperfunctional in focal dystonia

Brain : a journal of neurology, 2017
K. Simonyan, H. Cho, Azadeh Hamzehei Sichani, Estée Rubien-Thomas, M. Hallett   +4 more
semanticscholar   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Iron Deficiency Without Anemia and Reduced Basal Ganglia Iron Content in Youths.

JAMA Netw Open
Fiani D, Kim JW, Hu M, Salas R, Heilbronner S, Powers J, Haque M, Dinh S, Huang X, Worthy D, Devaraj S, Xu J, Calarge C.   +12 more
europepmc   +1 more source

Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's disease. [PDF]

Front Neurosci
Presbrey KN, Wozny TA, Louie KH, Little S, Starr PA, Abbasi-Asl R, Wang DD.   +6 more
europepmc   +1 more source