Results 21 to 30 of about 240,344 (282)

Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Neurobiology of Disease, 2016
Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of ...
Irene Sebastianutto, Natallia Maslava, Corey R. Hopkins, M. Angela Cenci   +3 more
doaj   +1 more source

Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia

Neurobiology of Disease, 2004
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD).
Christine Konradi, Jenny E. Westin, Manolo Carta, Molly E. Eaton, Katarzyna Kuter, Andrzej Dekundy, Martin Lundblad, M. Angela Cenci   +7 more
doaj   +1 more source

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

Neurobiology of Disease, 2011
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo, Alessandra Recchia, Nataljia Popovic, Daniel Andersson, Hans Nissbrandt, M. Angela Cenci   +5 more
doaj   +1 more source

Cerebellum: an explanation for dystonia? [PDF]

, 2017
Dystonia is a movement disorder that is characterized by involuntary muscle contractions, abnormal movements and postures, as well as by non-motor symptoms, and is due to abnormalities in different brain areas.
Berardelli, Alfredo, Bologna, Matteo
core   +1 more source

Integration of navigation and action selection functionalities in a computational model of cortico-basal ganglia-thalamo-cortical loops [PDF]

, 2005
This article describes a biomimetic control architecture affording an animat both action selection and navigation functionalities. It satisfies the survival constraint of an artificial metabolism and supports several complementary navigation strategies ...
Berthoz, Alain, Filliat, David, Girard, Benoît, Guillot, Agnès, Meyer, Jean-Arcady   +4 more
core   +4 more sources

Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease

Neurobiology of Disease, 2009
Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane, Patrik Brundin, M. Angela Cenci   +2 more
doaj   +1 more source

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease

Neurobiology of Disease, 2008
The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease (PD).
E.L. Lane, D. Soulet, L. Vercammen, M.A. Cenci, P. Brundin   +4 more
doaj   +1 more source

Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]

, 1990
The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Adler, Anderson, Avnur, Bodick, Bonhoeffer, Bovolenta, Condic, Davis, DeLong, Dodd, Dow, Dziadek, Dziadek, Easter, Fallon, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Hantaz-Ambroise, Harris, Hinds, Holley, Holt, Kanwar, Kuffler, Kuwada, Letourneau, Manthorpe, Matsusaka, Nakamura, Nardi, Newgreen, Newgreen, Nordlander, Patterson, Puelles, Rager, Reynolds, Roberts, Rogers, Rösner, Rösner, Sanes, Scherer, Schittny, Silver, Singer, Thanos, Thanos, Thanos, Timpl, Timpl, Vanselow, Walter, Walter, Williams   +58 more
core   +1 more source

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat

Neurobiology of Disease, 2006
Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia.
E.L. Lane, C. Winkler, P. Brundin, M.A. Cenci   +3 more
doaj   +1 more source

Autoimmune basal ganglia encephalitis associated with anti-recoverin antibodies: A case report

eNeurologicalSci, 2021
Autoimmune basal ganglia encephalitis causes neurological symptoms such as parkinsonism associated with basal ganglia lesions. Here, we report a case of autoimmune basal ganglia encephalitis without retinal lesions or malignancy harboring anti-recoverin ...
Yuki Kitazaki, Norimichi Shirafuji, Naoko Takaku, Tomohisa Yamaguchi, Soichi Enomoto, Masamichi Ikawa, Osamu Yamamura, Yasunari Nakamoto, Tadanori Hamano   +8 more
doaj   +1 more source