Results 21 to 30 of about 250,907 (309)
Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]
, 1990 The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Adler +58 more
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Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]
, 2020 Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S. +8 more
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Neurobiology of Disease, 2016 Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of ...
Irene Sebastianutto +3 more
doaj +1 more source
A basal ganglia inspired model of action selection evaluated in a robotic survival task. [PDF]
, 2003 The basal ganglia system has been proposed as a possible neural substrate for action selection in the vertebrate brain. We describe a robotic implementation of a model of the basal ganglia and demonstrate the capacity of this system to generate adaptive ...
Cuzin, V. +4 more
core +3 more sources
Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia
Neurobiology of Disease, 2004 We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD).
Christine Konradi +7 more
doaj +1 more source
Neurobiology of Disease, 2011 6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo +5 more
doaj +1 more source
Integration of navigation and action selection functionalities in a computational model of cortico-basal ganglia-thalamo-cortical loops [PDF]
, 2005 This article describes a biomimetic control architecture affording an animat both action selection and navigation functionalities. It satisfies the survival constraint of an artificial metabolism and supports several complementary navigation strategies ...
Berthoz, Alain +4 more
core +3 more sources
Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]
, 2012 Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor ...
Park, Choongseok, Rubchinsky, Leonid
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Neurobiology of Disease, 2009 Serotonin has been postulated to play a role in the transplant-induced involuntary movements that occur following intrastriatal grafts of ventral mesencephalic tissue in the treatment of Parkinson's disease.
Emma Louise Lane +2 more
doaj +1 more source
Cerebellum: an explanation for dystonia? [PDF]
, 2017 Dystonia is a movement disorder that is characterized by involuntary muscle contractions, abnormal movements and postures, as well as by non-motor symptoms, and is due to abnormalities in different brain areas.
Berardelli, Alfredo, Bologna, Matteo
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