Rethinking the external globus pallidus and information flow in cortico-basal ganglia-thalamic circuits [PDF]
arXiv, 2023 For decades the external globus pallidus (GPe) has been viewed as a passive way-station in the indirect pathway of the cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to this model, one-way descending striatal signals in the indirect pathway amplify the suppression of downstream ...
arxiv
Effects of electrical and optogenetic deep brain stimulation on synchronized oscillatory activity in Parkinsonian basal ganglia [PDF]
IEEE Trans Neural Syst Rehabil Eng 25:2188-2195, 2017, 2017 Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic stimulation is an effective experimental stimulation technique to affect pathological network dynamics.
arxiv +1 more source
Emotions and cognitive control: A comparison of bipolar disorder and schizophrenia
Journal of Affective Disorders Reports, 2021 Background: Bipolar disorder (BP) and schizophrenia (SZ) are both psychiatric conditions characterized by deficits in cognitive control (executive function and attention) and emotion regulation. The emotional Stroop task makes it possible to measure such
Murielle Sollier-Guillery +6 more
doaj
PDZD8 is not the ‘functional ortholog’ of Mmm1, it is a paralog [version 1; referees: 2 approved]
F1000Research, 2018 Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells.
Jeremy G. Wideman +3 more
doaj +1 more source
MARTI-4: new model of human brain, considering neocortex and basal ganglia -- learns to play Atari game by reinforcement learning on a single CPU [PDF]
arXiv, 2022 We present Deep Control - new ML architecture of cortico-striatal brain circuits, which use whole cortical column as a structural element, instead of a singe neuron. Based on this architecture, we present MARTI - new model of human brain, considering neocortex and basal ganglia.
arxiv
Neuroimaging of Basal Ganglia in Neurometabolic Diseases in Children
Brain Sciences, 2020 Diseases primarily affecting the basal ganglia in children result in characteristic disturbances of movement and muscle tone. Both experimental and clinical evidence indicates that the basal ganglia also play a role in higher mental states.
Justyna Paprocka +3 more
doaj +1 more source
Mean-field modeling of the basal ganglia-thalamocortical system. II. Dynamics of parkinsonian oscillations [PDF]
J. Theor. Biol. 257:664-688 (2009), 2018 Neuronal correlates of Parkinson's disease (PD) include a slowing of the electroencephalogram (EEG) and enhanced synchrony at 3-7 and 7-30 Hz in the basal ganglia, thalamus, and cortex. This study describes the dynamics of a physiologically based mean-field model of the basal ganglia-thalamocortical system, and shows how it accounts for key ...
arxiv +1 more source
Real-Time Recurrent Reinforcement Learning [PDF]
, 2023 We introduce a biologically plausible RL framework for solving tasks in partially observable Markov decision processes (POMDPs). The proposed algorithm combines three integral parts: (1) A Meta-RL architecture, resembling the mammalian basal ganglia; (2) A biologically plausible reinforcement learning algorithm, exploiting temporal difference learning ...
arxiv +1 more source
Mean-field modeling of the basal ganglia-thalamocortical system. I. Firing rates in healthy and parkinsonian states [PDF]
J. Theor. Biol. 257: 642-663 (2009), 2018 Parkinsonism leads to various electrophysiological changes in the basal ganglia-thalamocortical system (BGTCS), often including elevated discharge rates of the subthalamic nucleus (STN) and the output nuclei, and reduced activity of the globus pallidus external segment (GPe).
arxiv +1 more source
A biologically inspired computational model of the Block Copying Task [PDF]
, 2003 We present in this paper a biologically inspired model of the Basal Ganglia which deals with Block Copying as a sequence learning task. By breaking a relatively complex task into simpler operations with well-defined skills, an approach which is termed as
Arnold, Michael +3 more
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