Results 81 to 90 of about 26,837,992 (363)

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

open access: yesMolecular Psychiatry, 2016
Inflammation and altered glutamate metabolism are two pathways implicated in the pathophysiology of depression. Interestingly, these pathways may be linked given that administration of inflammatory cytokines such as interferon-α to otherwise non ...
E. Haroon   +7 more
semanticscholar   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

open access: yesAdvanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim   +3 more
wiley   +1 more source

Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia

open access: yesNeurobiology of Disease, 2004
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (l-DOPA)-induced dyskinesia and Parkinson disease (PD).
Christine Konradi   +7 more
doaj  

Microsurgical and Functional Linguistic Anatomy of Cerebral Basal Ganglia

open access: yesİstanbul Medical Journal, 2020
Introduction:The central core of the cerebral hemispheres is located on the medial side of the insular cortex. It is made up of basal ganglia and white matter tracts.
Mustafa Güdük   +3 more
doaj   +1 more source

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

open access: yesAdvanced Functional Materials, EarlyView.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong   +7 more
wiley   +1 more source

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

open access: yesNeurobiology of Disease, 2011
6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-
Veronica Francardo   +5 more
doaj  

Obsessive Compulsive Disorder in a Woman with Left Basal Ganglia Infarct: A Case Report

open access: yesBehavioural Neurology, 1997
This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia ...
Faustino Lopez-Rodriguez   +2 more
doaj   +1 more source

Reward functions of the basal ganglia

open access: yesJournal of neural transmission, 2016
Besides their fundamental movement function evidenced by Parkinsonian deficits, the basal ganglia are involved in processing closely linked non-motor, cognitive and reward information.
W. Schultz
semanticscholar   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

open access: yesAdvanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell   +5 more
wiley   +1 more source

Resting Hyperperfusion of the Hippocampus, Midbrain, and Basal Ganglia in People at High Risk for Psychosis.

open access: yesAmerican Journal of Psychiatry, 2016
OBJECTIVE Animal models suggest that the development of psychosis involves hyperactivity in the hippocampus that drives increased activity in the midbrain and basal ganglia.
P. Allen   +8 more
semanticscholar   +1 more source

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