Results 81 to 90 of about 27,260,641 (372)

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

Molecular Psychiatry, 2016
Inflammation and altered glutamate metabolism are two pathways implicated in the pathophysiology of depression. Interestingly, these pathways may be linked given that administration of inflammatory cytokines such as interferon-α to otherwise non ...
E. Haroon, C. Fleischer, J. Felger, Xiangchuan Chen, B. Woolwine, Trusharth Patel, Xiaoping Hu, Andrew H. Miller   +7 more
semanticscholar   +1 more source

Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI.

, 2004
Gradient echo T2*-weighted MRI has high sensitivity in detecting cerebral microbleeds, which appear as small dot-like hypointense lesions. Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic ...
Brown, Martin M, Cipolotti, Lisa, Coward, Lucy J, Frazer, Duncan W, Jäger, H Rolf, Losseff, Nick A, Watt, Hilary, Werring, David J   +7 more
core   +1 more source

Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures

Advanced Healthcare Materials, EarlyView.
SiNW mat‐based MEA (NW_MEA) enables continuous intracellular recordings from neurons in primary rat DRG cell cultures, identifying C‐fiber nociceptors. Supported by an astrocyte feeder layer, SiNW mat promotes DRG neuron and glial cell growth, preserving in vivo‐like cell characteristics and allowing drug‐modulated activity monitoring.
Ivano Lucarini, Francesco Maita, Giorgia Conte, Emanuela Saracino, Francesco Formaggio, Elena Palmieri, Roberta Fabbri, Aikaterini Konstantoulaki, Chiara Lazzarini, Marco Caprini, Valentina Benfenati, Luca Maiolo, Annalisa Convertino   +12 more
wiley   +1 more source

Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion

Neurobiology of Disease, 2016
Mice with striatal 6-hydroxydopamine (6-OHDA) lesions are widely used as a model to study the effects of neurorestorative, symptomatic, or antidyskinetic treatments for Parkinson's disease (PD).
Francesco Bez, Veronica Francardo, M. Angela Cenci   +2 more
doaj  

AN EXAMINATION OF CONCURRENT DISCRIMINATION LEARNING WITHIN INDIVIDUALS WITH PARKINSON’S DISEASE [PDF]

, 2013
The main focus of this research is to further understand memory formation by examining the role of the basal ganglia in learning. Broadly, this study examines how the basal ganglia may play a role in a task that has been associated with declarative ...
Tuladhar, Darshana
core   +1 more source

Temporal discrimination: Mechanisms and relevance to adult-onset dystonia [PDF]

, 2017
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Beck, Rebecca, Conte, Antonella, Hutchinson, Michael, Killian, Owen, Mcgovern, Eavan M., Narasimham, Shruti, O'Riordan, Sean, Reilly, Richard B.   +7 more
core   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

The substantia Nigra pars compacta and temporal processing [PDF]

, 2006
The basal ganglia and cerebellum are considered to play a role in timing, although their differential roles in timing remain unclear. It has been proposed that the timing of short milliseconds-range intervals involves the cerebellum, whereas longer ...
Dirnberger, G., Frith, C.D., Jahanshahi, M., Jones, C.R.G.   +3 more
core  

Does the motor system need intermittent control? [PDF]

, 2014
Explanation of motor control is dominated by continuous neurophysiological pathways (e.g. trans-cortical, spinal) and the continuous control paradigm.
Brembs, Cisek, Cohen, Cornelis van de Kamp, Diedrichsen, Dux, Frank, Gawthrop, Gawthrop, Gawthrop, Gawthrop, Gollee, Haber, Hardwick, Henrik Gollee, Houk, Ian David Loram, Kleinman, Lakie, Levison, Loram, Loram, Loram, Loram, Loram, Loram, Marsden, Martin Lakie, Peter J. Gawthrop, Pruszynski, Redgrave, Redgrave, Ronco, Todorov, Van De Kamp, Van de Kamp, Vince, Yin   +37 more
core   +2 more sources

Structured Light Projection Using Image Guide Fibers for In Situ Photo‐biofabrication

Advanced Materials, EarlyView.
Light‐based biofabrication is typically performed with single wavelength light sources and within benchtop devices. This work demonstrates FaSt‐Light (Fiber‐assisted Structured Light) as a new approach to achieve multiwavelength image projection using flexible image guide fibers, which enables a variety of applications for in situ biofabrication ...
Parth Chansoria, Michael Winkelbauer, Shipin Zhang, Jakub Janiak, Hao Liu, Dimitar Boev, Andrea Morandi, Rachel Grange, Marcy Zenobi‐Wong   +8 more
wiley   +1 more source