Karak syndrome: a novel degenerative disorder of the basal ganglia and cerebellum [PDF]
, 2003 Two brothers are reported with early onset progressive cerebellar ataxia, dystonia, spasticity, and intellectual decline. • Neuroradiology showed cerebellar atrophy and features compatible with iron deposition in the putamen (including the “eye of ...
Dheyyat, M. +9 more
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Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease [PDF]
Frontiers in Cellular Neuroscience, 2022 Parkinson’s disease (PD) is a neurodegenerative disease usually caused by neuroinflammation, oxidative stress and other etiologies. Recent studies have found that the cannabinoid system present in the basal ganglia has a strong influence on the progression of PD.
Mengya Wang, Huayuan Liu, Zegang Ma
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Temporal discrimination: Mechanisms and relevance to adult-onset dystonia [PDF]
, 2017 Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Beck, Rebecca +7 more
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Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease [PDF]
International Journal of Molecular Sciences, 2021 With the increasing age of the population, the incidence of Parkinson’s disease (PD) has increased exponentially. The development of novel therapeutic interventions requires an understanding of the involvement of senescent brain cells in the pathogenesis of PD.
Mohammed E. Choudhury +2 more
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The biochemistry of the basal ganglia and Parkinson's disease [PDF]
Postgraduate Medical Journal, 1977 SummaryThe metabolic pathways for five transmitters in the basal ganglia are briefly described; the results of determinations of their concentrations, of their rate-limiting enzymes and of their degradation products are summarized. The changes found in Parkinson's disease are described. While dopamine synthesis in the basal ganglia is defective in this
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Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals. [PDF]
, 2011 We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications.
Atkinson, J Hampton +17 more
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Neural indicators of fatigue in chronic diseases : A systematic review of MRI studies [PDF]
, 2018 The authors would like to thank the Sir Jules Thorn Charitable Trust for their financial support.Peer reviewedPublisher ...
Basu, Neil +3 more
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p75NTR in Huntington's disease: beyond the basal ganglia
Oncotarget, 2015 Huntington’s disease (HD) is a fatal neurodegenerative disorder with a characteristic phenotype including chorea and dystonia, uncoordinated fine movements, cognitive decline and psychiatric disturbances. Even though the clinical diagnosis of HD relies on the manifestation of motor abnormalities, the associated memory ...
Brito, Verónica, Ginés Padrós, Silvia
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Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron +3 more
wiley +1 more source
Illuminating basal ganglia and beyond in Parkinson's disease
Movement Disorders, 2018 International ...
Vaillancourt, David, +1 more
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