Results 81 to 90 of about 161,553 (288)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. [PDF]

, 2015
Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies ...
Annamalai, P, Cesani, F, Chao, T, Chondronikola, M, Porter, C, Saraf, MK, Sidossis, LS   +6 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Atributos biológicos indicadores da qualidade do solo em pastagem cultivada e nativa no Pantanal Biological indicator attributes of soil quality under cultivated and natural pasture in the Pantanal wetlands

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi avaliar as alterações nos atributos biológicos do solo, em razão da conversão floresta nativa pastagem cultivada e submissão de pastagens nativas a sistema pastejo contínuo, um Neossolo Quartzarênico, no Pantanal sul-mato ...
Evaldo Luis Cardoso, Marx Leandro Naves Silva, Fátima Maria de Souza Moreira, Nilton Curi   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Mineralização do carbono orgânico em solos tratados com lodo de curtume Mineralization of the organic carbon in soils treated with tannery sludges

Pesquisa Agropecuária Brasileira, 2006
O objetivo deste trabalho foi avaliar a mineralização do carbono orgânico do lodo de curtume, aplicado em solos com diferentes classes texturais, de modo a caracterizar a cinética do processo de mineralização e auxiliar na elaboração de normas técnicas ...
Alexandre Martin Martines, Cristiano Alberto de Andrade, Elke Jurandy Bran Nogueira Cardoso   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Carbon of microbial biomass in Al-Fe-humus soils of the northwestern Russia

Бюллетень Почвенного института им. В.В. Докучаева
The study was carried out in blueberry pine forests of the middle taiga subzone of Karelia. The results of complex studies of the microbiocenosis of Al-Fe-humus soils (Albic Podzols) formed on fluvioglacial deposits are presented.
M. V. Medvedeva, D. A. Nikitin, M. V. Semenov, G. V. Akhmetova   +3 more
doaj   +1 more source

Drivers of inter-year variability of plant production and decomposers across contrasting island ecosystems [PDF]

, 2012
Despite the likely importance of inter-year dynamics of plant production and consumer biota for driving community- and ecosystem-level processes, very few studies have explored how and why these dynamics vary across contrasting ecosystems.
Bardgett, Richard, Jonsson, Micael, Kalela-Brundin, Maarit, Lagerström, Anna, Nilsson, Marie-Charlotte, Wardle, David A., Yeates, Gregor   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source