Results 221 to 230 of about 59,918 (258)
Some of the next articles are maybe not open access.
Base excision and nucleotide excision repair pathways in mycobacteria
Tuberculosis, 2011About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount ...
Kurthkoti, Krishna, Varshney, Umesh
openaire +3 more sources
Targeting Base Excision Repair for Chemosensitization
Anti-Cancer Agents in Medicinal Chemistry, 2008In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in the clinic have the ability to induce
Sanjay, Adhikari +5 more
openaire +2 more sources
Base excision repair in yeast and mammals
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA damages. Many of these damages arise spontaneously because DNA interacts with the cellular milieu, and so BER profoundly influences spontaneous mutation rates. In addition, BER
A, Memisoglu, L, Samson
openaire +2 more sources
Base excision repair in nucleosome substrates
Chromosome Research, 2006Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with ...
Indu, Jagannathan +2 more
openaire +2 more sources
Enzymology of mitochondrial base excision repair
2001A number of laboratories have shown that those types of DNA damage that are generally reparable by base excision repair are efficiently repaired in mtDNA. In contrast, most types of damage that require other sorts of repair machinery are not effectively repaired in mtDNA.
D F, Bogenhagen +2 more
openaire +2 more sources
DNA modifications repaired by base excision repair are epigenetic
DNA Repair, 2013CREB controls ∼25% of the mammalian transcriptome. Small changes in binding to its consensus (CRE) sequence are likely to be amplified many fold in initiating transcription. Here we show that DNA lesions repaired by the base excision repair (BER) pathway modulate CREB binding to CRE. We generated Kd values by electrophoretic mobility shift assays using
Stephen P G, Moore +2 more
openaire +2 more sources
Analysis of base excision and nucleotide excision repair in Candida albicans
Microbiology, 2008Candida albicans, clinically the most important human fungal pathogen, rapidly develops resistance to antifungal drugs. The acquisition of resistance has been linked to various types of genome changes. As part of an ongoing study of this problem, we investigated mutation, genome stability and drug resistance acquisition in C.
Melanie, Legrand +3 more
openaire +2 more sources
Base Excision Repair in Mammalian Cells
2008A rapid, convenient and safe in vitro assay system for base excision repair is described. Whole cell extracts are prepared by detergent-based cell lysis and provide a vigorous activity of AP site repair. A circular DNA substrate is used for detection of both DNA polymerase beta-dependent and proliferating cell nuclear antigen (PCNA)-dependent pathways.
openaire +2 more sources
Breakage of cytoplasmic chromosomes by pathological DNA base excision repair
Nature, 2022David Pellman +2 more
exaly