Results 71 to 80 of about 168,088 (301)

DNA functionalization by dynamic chemistry

Beilstein Journal of Organic Chemistry, 2016
Dynamic combinatorial chemistry (DCC) is an attractive method to efficiently generate libraries of molecules from simpler building blocks by reversible reactions under thermodynamic control.
Zeynep Kanlidere, Oleg Jochim, Marta Cal, Ulf Diederichsen   +3 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

Nature Communications
Cytosine base editors enable programmable and efficient genome editing using an intermediate featuring a U•G mismatch across from a DNA nick. This intermediate facilitates two major outcomes, C•G to T•A and C•G to G•C point mutations, and it is not ...
Sifeng Gu, Zsolt Bodai, Rachel A. Anderson, Hei Yu Annika So, Quinn T. Cowan, Alexis C. Komor   +5 more
doaj   +1 more source

Competitive Oligonucleotide Single-Base Extension Combined with Mass Spectrometric Detection for Mutation Screening

BioTechniques, 1997
A rapid, robust and widely applicable mutation detection scheme not requiring radioactivity or gel-based detection is introduced. It is a single-tube, competitive oligonucleotide single-base extension (COSBE) reaction using a pair of primers with the 3 ...
G. Scott Higgins, Daniel P. Little, Hubert Köster   +2 more
doaj   +1 more source

1H NMR determination of base‐pair lifetimes in oligonucleotides containing single base mismatches [PDF]

Nucleic Acids Research, 2002
Proton nuclear magnetic resonance (NMR) spectroscopy is employed to characterize the kinetics of base-pair opening in a series of 9mer duplexes containing different single base mismatches. The imino protons from the different mismatched, as well as fully matched, duplexes are assigned from the imino-imino region in the WATERGATE NOESY spectra.
Bhattacharya, Pratip K., Cha, Julie, Barton, Jacqueline K.   +2 more
openaire   +3 more sources

Remote state preparation of a photonic quantum state via quantum teleportation [PDF]

, 2013
We demonstrate an experimental realization of remote state preparation via the quantum teleportation algorithm, using an entangled photon pair in the polarization degree of freedom as the quantum resource. The input state is encoded on the path of one of
Knoll, Laura T., Larotonda, Miguel A., Schmiegelow, Christian T.   +2 more
core   +2 more sources

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Mismatch repair balances leading and lagging strand DNA replication fidelity.

PLoS Genetics, 2012
The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform ...
Scott A Lujan, Jessica S Williams, Zachary F Pursell, Amy A Abdulovic-Cui, Alan B Clark, Stephanie A Nick McElhinny, Thomas A Kunkel   +6 more
doaj   +1 more source

Sequence variants affecting the genome-wide rate of germline microsatellite mutations

Nature Communications, 2023
Microsatellites are polymorphic tracts of short tandem repeats with one to six base-pair (bp) motifs and are some of the most polymorphic variants in the genome.
Snaedis Kristmundsdottir, Hakon Jonsson, Marteinn T. Hardarson, Gunnar Palsson, Doruk Beyter, Hannes P. Eggertsson, Arnaldur Gylfason, Gardar Sveinbjornsson, Guillaume Holley, Olafur A. Stefansson, Gisli H. Halldorsson, Sigurgeir Olafsson, Gudny. A. Arnadottir, Pall I. Olason, Ogmundur Eiriksson, Gisli Masson, Unnur Thorsteinsdottir, Thorunn Rafnar, Patrick Sulem, Agnar Helgason, Daniel F. Gudbjartsson, Bjarni V. Halldorsson, Kari Stefansson   +22 more
doaj   +1 more source

Identification of I:A mismatch base-pairing structure in DNA.

Journal of Biological Chemistry, 1987
Deoxyoligonucleotides containing deoxyinosine residues at positions corresponding to ambiguous nucleotides derived from an amino acid sequence have been successfully used as hybridization probes. It is assumed that the hypoxanthine residue can make base pairs with multiple bases.
S, Uesugi, Y, Oda, M, Ikehara, Y, Kawase, E, Ohtsuka   +4 more
openaire   +2 more sources