Results 101 to 110 of about 353,589 (332)

Capturing alternative secondary structures of RNA by decomposition of base-pairing probabilities

BMC Bioinformatics, 2018
Background It is known that functional RNAs often switch their functions by forming different secondary structures. Popular tools for RNA secondary structures prediction, however, predict the single ‘best’ structures, and do not produce alternative ...
Taichi Hagio, Shun Sakuraba, Junichi Iwakiri, Ryota Mori, Kiyoshi Asai   +4 more
doaj   +1 more source

Can re-entrance be observed in force induced transitions?

, 2009
A large conformational change in the reaction co-ordinate and the role of the solvent in the formation of base-pairing are combined to settle a long standing issue {\it i.e.} prediction of re-entrance in the force induced transition of DNA.
Bhattacharjee S. M., Broude N. E., de Gennes P. G., Howley P. M., Hutton J. M., Kumar S., Kumar S., Kumar S., Kumar S., Mishra P. K., Sanjay Kumar, Straeten E. V.   +11 more
core   +1 more source

Structural Effect of Organic Catalytic Pairs Based on Chiral Amino(thio)ureas and Phosphazene Bases for the Isoselective Ring-Opening Polymerization of Racemic Lactide

, 2023
Mohamed Samir Zaky, Gilles Guichard, Daniel Taton   +2 more
openalex   +2 more sources

Effects of individual base-pairs on in vivo target search and destruction kinetics of small RNA [PDF]

, 2020
Anustup Poddar, Muhammad S. Azam, Tunc Kayikcioglu, Maksym Bobrovskyy, Jichuan Zhang, Xiangqian Ma, Piyush Labhsetwar, Jingyi Fei, Digvijay Singh, Zaida Luthey‐Schulten, Carin K. Vanderpool, Taekjip Ha   +11 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Thermodynamics of base pairing

Current Opinion in Structural Biology, 1996
The study of the thermodynamics of base pairing is a rapidly expanding field due to its importance for taking advantage of opportunities presented by the growing database of nucleic acid sequences. Both natural and unnatural nucleic acids are being studied.
openaire   +2 more sources

Design of flower transplanting mechanisms based on double planet carrier non-circular gear train with complete rotation kinematic pair

, 2022
Xiong Zhao, Xingxiao Ma, Hongwei Liao, Yongsen Xiong Yadan Xu, Jianneng Chen   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

RNS arithmetic in 𝔽pk and application to fast pairing computation

Journal of Mathematical Cryptology, 2011
In this work, we are interested in arithmetic on large prime field and their extensions of small degree. We explain why it is very interesting to use RNS arithmetic for the base field 𝔽p when computations in 𝔽pk have to be done, essentially thanks to ...
Duquesne Sylvain
doaj   +1 more source

DNA Repair in Mammalian Cells: Mismatched repair: variations on a theme [PDF]

, 2018
.: Complementary base pairing underlies the genetic template function of the DNA double helix. Therefore, to assure faithful DNA transactions, cells must adhere to a strict application of the Watson-Crick base pairing principle.Yet, mispairing does arise
Kunz, C., Saito, Y., Schär, P.
core