Results 101 to 110 of about 32,528,266 (371)

Effect of the Base-Pair Sequence on B-DNA Thermal Conductivity [PDF]

, 2021
Vignesh Mahalingam, Dineshkumar Harursampath   +1 more
openalex   +1 more source

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase

PLoS ONE, 2013
T-705 (Favipiravir) is a broad-spectrum antiviral molecule currently in late stage clinical development for the treatment of influenza virus infection.
Zhinan Jin, L. K. Smith, V. Rajwanshi, Baek Kim, J. Deval   +4 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water

Nature Communications, 2018
Arabinonucleic acid (ANA) Watson-Crick base-pair with RNA/DNA and can evolve to display enzyme-like function. Here, the authors now identify a prebiotic pathway that yields the complete set of Watson-Crick base-pairing purine and pyrimidine ANA ...
Samuel J. Roberts, Rafał Szabla, Zoe R. Todd, Shaun Stairs, Dejan-Krešimir Bučar, Jiří Šponer, Dimitar D. Sasselov, Matthew W. Powner   +7 more
doaj   +1 more source

Unusual base pairing during the decoding of a stop codon by the ribosome

Nature, 2013
During normal translation, the binding of a release factor to one of the three stop codons (UGA, UAA or UAG) results in the termination of protein synthesis. However, modification of the initial uridine to a pseudouridine (Ψ) allows efficient recognition
I. S. Fernández, C. Ng, C. Ng, A. Kelley, Guowei Wu, Yi‐Tao Yu, V. Ramakrishnan   +6 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Base-stacking and base-pairing contributions into thermal stability of the DNA double helix

Nucleic Acids Research, 2006
Two factors are mainly responsible for the stability of the DNA double helix: base pairing between complementary strands and stacking between adjacent bases.
Peter Yakovchuk, E. Protozanova, M. Frank-Kamenetskii   +2 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Covering All the Bases in Genetics: Simple Shorthands and Diagrams for Teaching Base Pairing to Biology Undergraduates

Journal of Microbiology & Biology Education, 2011
Explaining base pairing is an important element in teaching undergraduate genetics. I propose a teaching approach that aims to close the gap between the mantra “A pairs with T, and G pairs with C” and the “intimidating” chemical diagrams.
Sergei Kuchin
doaj   +1 more source

A Fair Power Allocation Approach to NOMA in Multi-user SISO Systems

, 2017
A non-orthogonal multiple access (NOMA) approach that always outperforms orthogonal multiple access (OMA) called Fair-NOMA is introduced. In Fair-NOMA, each mobile user is allocated its share of the transmit power such that its capacity is always greater
Oviedo, Jose Armando, Sadjadpour, Hamid R.   +1 more
core   +1 more source