Results 71 to 80 of about 353,589 (332)
A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. [PDF]
PLoS ONE, 2009 Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes.
Tao Li, Erkang Wang, Shaojun Dong
doaj +1 more source
Dissociation of ssDNA - Single-Walled Carbon Nanotube Hybrids by Watson-Crick Base Pairing
, 2010 The unwrapping event of ssDNA from the SWNT during the Watson-Crick base paring is investigated through electrical and optical methods, and binding energy calculations.
Brown S. D. M. +30 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Unusual Nucleic acid nanostructures based on G-quadruplex DNA
ACI Avances en Ciencias e Ingenierías, 2015 A nano-assembly based on non-canonical DNA structures is reported. For the nanofabrication of a DNA-based structure the self-assembly of guanine quadruplex (Hoogsteen base pairing) and double-stranded DNA (Watson-Crick base pairing) was exploited.
Miguel Angel Méndez
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Teaching the Central Dogma of Molecular Biology using Jewelry
Journal of Microbiology & Biology Education, 2012 ”Cracking the Code” is an activity developed to demonstrate the processes of transcription and translation. This hands-on activity helps students understand the relationship between form (base pairing) and function (information storage and transfer) of ...
Jennifer M. DeBruyn
doaj +1 more source
Absence of extended states in a ladder model of DNA [PDF]
, 2006 We consider a ladder model of DNA for describing carrier transport in a fully coherent regime through finite segments. A single orbital is associated to each base, and both interstrand and intrastrand overlaps are considered within the nearest-neighbor ...
Diaz, E. +3 more
core +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Factor-4 and 6 compression of cyclotomic subgroups of and
Journal of Mathematical Cryptology, 2010 Bilinear pairings derived from supersingular elliptic curves of embedding degrees 4 and 6 over finite fields 𝔽2m and 𝔽3m, respectively, have been used to implement pairing-based cryptographic protocols.
Karabina Koray
doaj +1 more source